2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 1,4-Anthraquinone

1,4-Anthraquinone 是一种有效的抗癌剂。1,4-Anthraquinone 阻断核苷转运，抑制大分子合成，诱导 DNA 碎片化，降低癌细胞生长和活力。1,4-Anthraquinone 可用于抗白血病研究。

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1,4-Anthraquinone Chemical Structure

1,4-Anthraquinone Chemical Structure

CAS No. : 635-12-1

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1,4-Anthraquinone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1].

IC50 & Target

DNA/RNA synthesis[1]
体外研究
(In Vitro)

1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1].
1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1].
1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1,4-Anthraquinone 相关抗体:

Cell Proliferation Assay[1]

Cell Line: L1210 cells
Concentration: 2.62 nM-1.6 μM
Incubation Time: 4 days
Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM.

Cell Viability Assay[1]

Cell Line: L1210 cells
Concentration: 2.62 nM-1.6 μM
Incubation Time: 4 days
Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.
分子量

208.21

Formula

C14H8O2
CAS 号
性状

固体

颜色

Yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB) HNMR (94 KB)

产品使用指南 (1538 KB)
参考文献

1,4-Anthraquinone 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Anthraquinone635-12-1DNA/RNA Synthesisanticancerantiproliferativemacromolecule synthesisDNA fragmentationleukemiaL1210 cellsInhibitorinhibitorinhibit

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