2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 12,13-DiHOME

12,13-DiHOME 是棕色脂肪组织 (BAT) 的刺激剂，也是一种产热脂肪因子，可激活 BAT 以响应寒冷。(±)12,13-DiHOME 通过促进 FA 转运蛋白 FATP1 和 CD36 向细胞膜的易位，激活 BAT 燃料摄取并增强耐寒性。(±)12,13-DiHOME 可用于代谢紊乱的研究。

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12,13-DiHOME Chemical Structure

12,13-DiHOME Chemical Structure

CAS No. : 263399-35-5

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规格 价格 是否有货 数量
500μg（318.01 μM * 5 mL in Methyl acetate） ￥13000
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12,13-DiHOME 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].

体内研究
(In Vivo)

12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice fed a high-fat diet[1]
Dosage: 1 μg/kg
Administration: Retro-orbitally injection; once daily for 2 weeks
Result: Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
Animal Model: To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1]
Dosage:
Administration: 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result: Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
分子量

314.46

Formula

C18H34O4
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (160 KB)

产品使用指南 (1538 KB)
参考文献

12,13-DiHOME 相关分类

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Keywords:

12,13-DiHOME263399-35-5Endogenous MetaboliteInhibitorinhibitorinhibit

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产品名称：
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目录号：
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