2. Immunology/Inflammation Apoptosis
  3. NO Synthase Apoptosis
  4. 1400W

1400W dihydrochloride 是 1400W (HY-18731) 的二盐酸盐形式。1400W 是一种慢速、紧密结合、高选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，Kd ≤7 nM。1400W 抑制小胶质细胞 iNOS 诱导，减少 NO 生成，从而减轻大鼠大脑皮层氧化应激和神经元细胞凋亡，改善急性低压缺氧复氧引起的空间记忆功能障碍。

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1400W Chemical Structure

1400W Chemical Structure

CAS No. : 180001-34-7

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1400W 的其他形式现货产品:

Customer Review

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1400W 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].

IC50 & Target

Ki: 2 µM (nNOS), 50 µM (eNOS)[1]
体外研究
(In Vitro)

1400W (60 μM, 1 h) 减少原代成体小胶质细胞中 NO、3-NT 和 MDA 的产生，并防止大脑皮层神经元细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1400W 相关抗体:
体内研究
(In Vivo)

1400W (0.1-10 mg/kg, 皮下注射, 一次) 抑制大鼠回肠渗漏，EC50 为 0.16 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

177.25

Formula

C10H15N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

1400W 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1400W180001-34-7W1400W 1400W-1400NO SynthaseApoptosisNitric oxide synthasesNOSiNOSneuronal NOSendothelial NOSmicroglialNOneuronal cellapoptosisInhibitorinhibitorinhibit

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目录号：
HY-18730
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