1. Immunology/Inflammation NF-κB
  2. STING NF-κB
  3. 3'2'-cGAMP disodium

3'2'-cGAMP disodium  (Synonyms: c[A(2',5')pG(3',5')p] disodium)

目录号: HY-137708A
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3'2'-cGAMP (c[A(2',5')pG(3',5')p]) disodium 是 3'2'-cGAMP (HY-137708) 的二钠盐。3'2'-cGAMP (c[A(2',5')pG(3',5')p]) 是一种环状鸟苷酸-腺苷酸 (cGAMP) 异构体。3'2'-cGAMP 对果蝇 STING (dSTING) 表现出高选择性,激活 dSTING-NF-κB 信号通路,诱导 Sting 调控基因的表达,并在体内赋予强效的抗病毒状态。3'2'-cGAMP 能够抵抗病毒 poxin 的切割。3'2'-cGAMP 可用于病毒感染研究。

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3'2'-cGAMP disodium

3'2'-cGAMP disodium Chemical Structure

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Other Forms of 3'2'-cGAMP disodium:

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生物活性

3'2'-cGAMP (c[A(2',5')pG(3',5')p]) disodium is the disodium of 3'2'-cGAMP (HY-137708). 3'2'-cGAMP (c[A(2',5')pG(3',5')p]) is a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) isomer. 3'2'-cGAMP exhibits high selectivity for Drosophila STING (dSTING), activating the dSTING-NF-κB signaling pathway, inducing the expression of Sting-regulated genes (Srg) and conferring a potent antiviral state in vivo. 3'2'-cGAMP is resistant to cleavage by viral poxins. 3'2'-cGAMP can be used for the study of viral infections[1].

分子量

718.37

Formula

C20H22N10Na2O13P2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

3'2'-cGAMP disodium 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
3'2'-cGAMP disodium
目录号:
HY-137708A
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