2. Immunology/Inflammation
  3. COX
  4. 3,9-Dihydroeucomin

3,9-DiHydreucomin (compound 12) 是一种天然同异黄酮化合物，具有较低的 COX-2 抑制活性。

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3,9-Dihydroeucomin

3,9-Dihydroeucomin Chemical Structure

CAS No. : 887375-68-0

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3,9-Dihydroeucomin 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys[1].

IC50 & Target[1]

COX-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
> 100 μM
Compound: 9
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
[PMID: 19689125]
B16-BL6 IC50
64.3 μM
Compound: 9
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay
[PMID: 19689125]
HT-1080 IC50
> 100 μM
Compound: 9
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay
[PMID: 19689125]
HUVEC GI50
> 100 μM
Compound: 5
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
HeLa IC50
> 100 μM
Compound: 9
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
[PMID: 19689125]
PANC-1 IC50
> 100 μM
Compound: 9
Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay
Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay
[PMID: 19689125]
Y79 GI50
> 100 μM
Compound: 5
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay
[PMID: 30951308]
分子量

300.31

Formula

C17H16O5
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 97.0%

COA (283 KB)

产品使用指南 (1538 KB)
参考文献

3,9-Dihydroeucomin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,9-Dihydroeucomin887375-68-0COXCyclooxygenasehomoisoflavonoidCOX-2Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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