4-(Dodecylamino)phenol  (Synonyms: p-DDAP; p-Dodecylaminophenol)

4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer^[1][2].

4-(Dodecylamino)phenol (p-DDAP) (0-10 μM; 72 h) induces growth arrest in NB-39-nu cells^[1].
p-DDAP (0.1, 0.2, 0.4, 10 μM; ) arrestes the cell cycle in the G0/G1 phase in dose-dependent manner^[1].
p-DDAP (0.2 μM; 48 h) induces apoptotosis without differentiation^[1].
p-DDAP (0.2, 0.4, 1 μM; 24 h, 72 h) induces apoptotic cell death through bcl-2 down-regulation and caspases activation^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

277.44

C₁₈H₃₁NO

25848-37-7

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Noriko Takahashi, et al. The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells. Cancer Lett  [Content Brief]