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  3. (5Z,2E)-CU-3

(5Z,2E)-CU-3 

目录号: HY-121638A
产品使用指南

(5Z,2E)-CU-3 是一种有效的选择性抗 DGKα 同工酶抑制剂,IC50 值为 0.6 μM,竞争性抑制 DGKα 对 ATP 的亲和力,Km 值为 0.48 mM。(5Z,2E)-CU-3 靶向 DGKα 催化区域,但不靶向调节区域。(5Z,2E)-CU-3 具有抗肿瘤和免疫原性作用,增强癌细胞的凋亡和 T 细胞的活化。

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(5Z,2E)-CU-3 Chemical Structure

(5Z,2E)-CU-3 Chemical Structure

CAS No. : 1815598-71-0

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Description

(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].

IC50 & Target

IC50: 0.6 μM (DGKα)[1]

Molecular Weight

392.47

Formula

C₁₆H₁₂N₂O₄S₃

CAS No.

1815598-71-0

SMILES

O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
(5Z,2E)-CU-3
目录号:
HY-121638A
需求量:

(5Z,2E)-CU-3

Cat. No.: HY-121638A