1. Protein Tyrosine Kinase/RTK
  2. c-Kit
  3. AZD3229 Tosylate

AZD3229 Tosylate 

目录号: HY-112802A 纯度: 99.80%
COA 产品使用指南

AZD3229 Tosylate 是一种有效的、广泛的突变型酪氨酸激酶受体 (KIT) 抑制剂,可用于开发研究胃肠道间质瘤。

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AZD3229 Tosylate Chemical Structure

AZD3229 Tosylate Chemical Structure

CAS No. : 2248003-71-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
5 mg ¥1850
In-stock
10 mg ¥2900
In-stock
25 mg ¥5300
In-stock
50 mg ¥8800
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of AZD3229 Tosylate:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZD3229 Tosylate is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.

IC50 & Target

KIT[1].

体外研究
(In Vitro)

AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM). AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects. Selectivity over KDR can be rationalised predominantly by the interaction of water molecules with the protein and ligand in the active site and its kinome selectivity is similar to the best of the approved GIST agents[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

651.71

Formula

C31H34FN7O6S

CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

DMSO 中的溶解度 : ≥ 100 mg/mL (153.44 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5344 mL 7.6721 mL 15.3442 mL
5 mM 0.3069 mL 1.5344 mL 3.0688 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

AZD3229 Tosylate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5344 mL 7.6721 mL 15.3442 mL 38.3606 mL
5 mM 0.3069 mL 1.5344 mL 3.0688 mL 7.6721 mL
10 mM 0.1534 mL 0.7672 mL 1.5344 mL 3.8361 mL
15 mM 0.1023 mL 0.5115 mL 1.0229 mL 2.5574 mL
20 mM 0.0767 mL 0.3836 mL 0.7672 mL 1.9180 mL
25 mM 0.0614 mL 0.3069 mL 0.6138 mL 1.5344 mL
30 mM 0.0511 mL 0.2557 mL 0.5115 mL 1.2787 mL
40 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9590 mL
50 mM 0.0307 mL 0.1534 mL 0.3069 mL 0.7672 mL
60 mM 0.0256 mL 0.1279 mL 0.2557 mL 0.6393 mL
80 mM 0.0192 mL 0.0959 mL 0.1918 mL 0.4795 mL
100 mM 0.0153 mL 0.0767 mL 0.1534 mL 0.3836 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
AZD3229 Tosylate
目录号:
HY-112802A
需求量: