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  4. Acetic acid

Acetic acid  (Synonyms: 乙酸)

目录号: HY-Y0319 纯度: 99.65%
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Acetic acid 是一种羧酸和短链脂肪酸 (SCFA)。Acetic acid 能激活 AMPK，增加 ROS、cleaved caspase 9 和 PPARα，并下调 SREBP-1c 和 ChREBP 的表达。Acetic acid 对酿酒酵母 W303-1A 具有抗真菌活性。Acetic acid 调节能量代谢。Acetic acid 对胃癌具有抗癌活性。Acetic acid 可诱发扭体反应和溃疡性结肠炎。Acetic acid 可用于胃癌、溃疡性结肠炎、肝脂肪变性和疼痛的研究。

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Acetic acid

Acetic acid Chemical Structure

CAS No. : 64-19-7

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Other Forms of Acetic acid:

Acetic acid 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Acetic acid is a carboxylic acid and short-chain fatty acid (SCFAs). Acetic acid activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Acetic acid exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Acetic acid regulates energy metabolism. Acetic acid has anticancer activity against gastric cancer. Acetic acid induces writhing reaction and ulcerative colitis. Acetic acid can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain[1][2][3][4][5][6][7][8][9].

IC50 & Target[1][2][3][4][5][6][7][8][9]

Microbial Metabolite

 

Human Endogenous Metabolite

 

PPARα

 

Caspase 9

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
12 μM
Compound: Acetate
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
[PMID: 28745893]
HEK293 EC50
250 μM
Compound: Acetate
Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Agonist activity at human GPCR43 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
[PMID: 28745893]
体外研究
(In Vitro)

Acetic acid (2-5 µM；24 h) 通过氧化应激诱导胃癌细胞 (RGK1) 选择性死亡，而对正常胃粘膜细胞 (RGM1) 影响较小[3]。
Acetic acid (20-200 mM；200 min) 诱导酿酒酵母 W303-1A 程序性细胞死亡[4]。
Acetic acid (5 mM；15 天) 抑制 Caco-2 细胞中双糖酶 (蔗糖酶、麦芽糖酶、海藻糖酶、乳糖酶) 活性的升高，但不影响细胞生长或葡萄糖转运[5]。
Acetic acid (1.8-7.2 mM；3 h) 通过消耗 ATP 来激活 AMPKα 信号通路，从而增加牛肝细胞中的 AMP/ATP 比率，上调脂质氧化基因，下调脂肪生成基因，降低细胞内甘油三酯含量[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acetic acid 相关抗体:

Western Blot Analysis[3]

Cell Line: Rat gastric mucosal cells (RGM1), cancerous gastric mucosal cells (RGK1)
Concentration: 0, 1, 2, 5, 10, 20 µM
Incubation Time: 24 h
Result: Increased monocarboxylic transporter 1 (MCT1) and cleaved caspase 9 in RGK1 cells.
Showed minor effects in RGM1 cells.

Western Blot Analysis[6]

Cell Line: Bovine hepatocytes
Concentration: 1.8 mM, 3.6 mM, 7.2 mM
Incubation Time: 3 h
Result: Increased AMPKα phosphorylation and activity, upregulated PPARα expression, downregulated SREBP-1c and ChREBP expression.
体内研究
(In Vivo)

Acetic acid (0.56%；腹腔注射) 可显著诱发 C57BL/6J 小鼠的扭体反应[7]。
Acetic acid (5% v/v；直肠滴注) 可诱发小鼠溃疡性结肠炎，导致体重减轻、腹泻、结肠炎症和组织损伤[8]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

60.05

Formula

C2H4O2
CAS 号
性状

液体（密度：1.049 g/cm3）

颜色

Colorless to light yellow

中文名称

乙酸
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.65%

COA (284 KB)

产品使用指南 (1538 KB)
参考文献

Acetic acid 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acetic acid64-19-7乙酸Endogenous MetaboliteAMPKReactive Oxygen Species (ROS)CaspasePPARFungalAMP-activated protein kinasePeroxisome proliferator-activated receptorswrithing reactionulcerative colitishepatic steatosisRGK1Caco-2Inhibitorinhibitorinhibit

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