2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ERB-196

ERB-196  (Synonyms: WAY-202196)

目录号: HY-19468 纯度: 99.89%
COA 产品使用指南

摩尔计算器

ERB-196 是一个非类固醇选择性雌激素受体-β (ERβ) 激动剂。

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ERB-196 Chemical Structure

ERB-196 Chemical Structure

CAS No. : 550997-55-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥2000
In-stock
5 mg ￥5000
In-stock
10 mg ￥8500
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

ERB-196 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist.

IC50 & Target

ERβ[1]
体内研究
(In Vivo)

ERB-196 is a nonsteroidal selective estrogen receptor-β (ERβ) agonist. ERB-196 significantly reduces histopathologic evidence of injury to the gastrointestinal mucosal surface (0.7±0.1 vs. 2.3±0.2 for control; p<0.05). The mucosal mass of 10-cm segments of small bowel mucosa shows better preservation of mucosal mass than control treatment (63±20 [ERB-196] vs. 31±24 [control]), but this difference fails to reach statistical significance (p<0.06). The administration of ERB-196 is highly effective in the prevention of lethality. Consistent with the neutropenic rat model, ERB-196 significantly increases survival when compare with vehicle control[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

279.27

Formula

C17H10FNO2
CAS 号
性状

固体

颜色

Light brown to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 16 mg/mL (57.29 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5808 mL 17.9038 mL 35.8076 mL
5 mM 0.7162 mL 3.5808 mL 7.1615 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

The neutropenic rat model of pseudomonas sepsis are used in this study. For the survival study, ERB-196 (50 mg/kg; n=12) or vehicle control (n=8) is administered daily by orogastric feeding beginning on day 4 after the first dose of cyclophosphamide and continuing for 8 days. Animals are assessed clinically and pathologically by measuring daily body weight, body temperature, presence of bacteremia, circulating endotoxin levels, and pathologic evidence of damage to the gastrointestinal epithelium and liver by light microscopy and electron microscopy. Blood and tissue samples are serially diluted in sterile saline and incubated at 37°C on pseudomonas agar for quantitative assessment of bacterial concentrations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

ERB-196 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 3.5808 mL 17.9038 mL 35.8076 mL 89.5191 mL
5 mM 0.7162 mL 3.5808 mL 7.1615 mL 17.9038 mL
10 mM 0.3581 mL 1.7904 mL 3.5808 mL 8.9519 mL
15 mM 0.2387 mL 1.1936 mL 2.3872 mL 5.9679 mL
20 mM 0.1790 mL 0.8952 mL 1.7904 mL 4.4760 mL
25 mM 0.1432 mL 0.7162 mL 1.4323 mL 3.5808 mL
30 mM 0.1194 mL 0.5968 mL 1.1936 mL 2.9840 mL
40 mM 0.0895 mL 0.4476 mL 0.8952 mL 2.2380 mL
50 mM 0.0716 mL 0.3581 mL 0.7162 mL 1.7904 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ERB-196550997-55-2WAY-202196ERB196ERB 196WAY202196WAY 202196Estrogen Receptor/ERRInhibitorinhibitorinhibit

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Inquiry Information

产品名称：
ERB-196
目录号：
HY-19468
需求量：

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