1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. TRP Channel
  3. ML204 hydrochloride

ML204 hydrochloride 

目录号: HY-12949A 纯度: 99.81%
COA 产品使用指南

ML204 hydrochloride 是一个有效的、选择性的 TRPC4/TRPC5 通道的抑制剂,较 TRPC6 的选择性高出 20 倍,不影响其他的 TRP 通道和电压门控的钠、钾或 Ca2+ 通道。

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ML204 hydrochloride Chemical Structure

ML204 hydrochloride Chemical Structure

CAS No. : 2070015-10-8

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ¥847
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5 mg ¥770
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10 mg ¥1200
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50 mg ¥4200
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100 mg ¥6200
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Other Forms of ML204 hydrochloride:

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查看 TRP Channel 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca2+ channels[1][2].

IC50 & Target[1][2]

TRPC4

 

TRPC5

 

体外研究
(In Vitro)

ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca2+ rise with an IC50 value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation[1].
ML204 hydrochloride blocks TRPC4β activity induced through either Gi/o stimulation by μ-opioid, 5HT1A serotonin, and M2 muscarinic receptors or Gq/11 stimulation by the endogenous M3-like muscarinic receptors[1].
ML204 hydrochloride blocks LPS-induced TRPC5 channel activity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nonfasted male C57BL/6 (2-3 months)[4]
Dosage: 1 mg/kg
Administration: Subcutaneous injection, twice a day, for 5 days (prior to LPS injection)
Result: Induces mortality associated with increased hypothermia in mice with LPS-induced systemic inflammatory response.
分子量

262.78

Formula

C15H19ClN2

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O 中的溶解度 : ≥ 30 mg/mL (114.16 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8055 mL 19.0273 mL 38.0546 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8055 mL 19.0273 mL 38.0546 mL 95.1366 mL
5 mM 0.7611 mL 3.8055 mL 7.6109 mL 19.0273 mL
10 mM 0.3805 mL 1.9027 mL 3.8055 mL 9.5137 mL
15 mM 0.2537 mL 1.2685 mL 2.5370 mL 6.3424 mL
20 mM 0.1903 mL 0.9514 mL 1.9027 mL 4.7568 mL
25 mM 0.1522 mL 0.7611 mL 1.5222 mL 3.8055 mL
30 mM 0.1268 mL 0.6342 mL 1.2685 mL 3.1712 mL
40 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3784 mL
50 mM 0.0761 mL 0.3805 mL 0.7611 mL 1.9027 mL
60 mM 0.0634 mL 0.3171 mL 0.6342 mL 1.5856 mL
80 mM 0.0476 mL 0.2378 mL 0.4757 mL 1.1892 mL
100 mM 0.0381 mL 0.1903 mL 0.3805 mL 0.9514 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
ML204 hydrochloride
目录号:
HY-12949A
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