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  3. Miriplatin

Miriplatin  (Synonyms: SM-11355)

目录号: HY-16325A 纯度: ≥98.0%
COA 产品使用指南

Miriplatin (SM-11355) 为有效的化疗剂,是烷化剂 (alkylator) 的一种。

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Miriplatin Chemical Structure

Miriplatin Chemical Structure

CAS No. : 141977-79-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
5 mg ¥500
In-stock
10 mg ¥700
In-stock
50 mg ¥1400
In-stock
100 mg ¥2200
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Other Forms of Miriplatin:

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.

体外研究
(In Vitro)

Miriplatin (SM-11355) suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Miriplatin (SM-11355) (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells[1]. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

764.00

Formula

C34H68N2O4Pt

CAS 号
性状

固体

颜色

White to off-white

中文名称

米铂

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

chloroform 中的溶解度 : 43.33 mg/mL (56.71 mM; 超声助溶; DMSO can inactivate Miriplatin's activity)

Acetone 中的溶解度 : < 1 mg/mL (insoluble; DMSO can inactivate Miriplatin's activity)

DMF 中的溶解度 : < 1 mg/mL (insoluble; DMSO can inactivate Miriplatin's activity)

H2O 中的溶解度 : < 0.1 mg/mL (insoluble; DMSO can inactivate Miriplatin's activity)

*Miriplatin is usually formulated as a suspension.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3089 mL 6.5445 mL 13.0890 mL
5 mM 0.2618 mL 1.3089 mL 2.6178 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

参考文献
Cell Assay
[2]

Aliquots of AH109A cells are plated into 24-well microplates. Following cell adherence (1 day), Lipiodol (LPD) alone and agents (Miriplatin, etc.) suspended in LPD are added to Falcon cell culture inserts, equipped with a 0.4-μm pore membrane on their bottom. After 7 days of incubation at 37°C in 5% CO2, the numbers of viable cells are examined using AlamarBlue. The IC50 value is defined as the concentration inhibiting cell growth by 50% compared with treatment with LPD alone. To examine platinum concentrations in the medium, agents suspended in LPD are added to Falcon cell culture inserts in wells containing the culture medium alone. The platinum concentrations are quantitatively analyzed by FAAS. Alternatively, aliquots of AH109A cells are plated into 96-well microplates. Following cell adherence (1 day), agents in aqueous solution are added. After 3 days of incubation at 37°C in 5% CO2, the numbers of viable cells are examined using AlamarBlue[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Rats[2]
Rats bearing a tumor approximately 100-250 mm3 in area are randomly allocated into different treatment groups and a control group, each of which consists of seven rats. Tumor diameters are measured with calipers, and estimated tumor area is calculated by the formula: (smaller diameter) × (larger diameter). All agents (Miriplatin, etc.) suspended in Lipiodol (LPD) and LPD alone are injected into the hepatic artery of tumor-bearing rats at the volume of 0.02 mL/head. The therapeutic dose of each agent is defined in this study as follows: Miriplatin (400 μg/head, 20 mg/mL in LPD), cisplatin (400 μg/head, 20 mg/mL) and zinostatin stimalamer (20 μg/head, 1 mg/mL). After the intra-hepatic arterial administration, the gastroduodenal artery and abdomen are closed with uninterrupted sutures. The tumor growth rate (%) is calculated with the following formula: A7/A70 × 100, where A7 is the estimated tumor area at day 7 and A70 is the estimated tumor area at the initiation of the treatment (day 0). The systemic toxicity of the treatments is assessed in terms of changes in body weight during the experiments. These are calculated as (W7 − W70)/W70 × 100 where W7 is body weight at day 7 and W70 is body weight at day 0[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
chloroform 1 mM 1.3089 mL 6.5445 mL 13.0890 mL 32.7225 mL
5 mM 0.2618 mL 1.3089 mL 2.6178 mL 6.5445 mL
10 mM 0.1309 mL 0.6545 mL 1.3089 mL 3.2723 mL
15 mM 0.0873 mL 0.4363 mL 0.8726 mL 2.1815 mL
20 mM 0.0654 mL 0.3272 mL 0.6545 mL 1.6361 mL
25 mM 0.0524 mL 0.2618 mL 0.5236 mL 1.3089 mL
30 mM 0.0436 mL 0.2182 mL 0.4363 mL 1.0908 mL
40 mM 0.0327 mL 0.1636 mL 0.3272 mL 0.8181 mL
50 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6545 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Miriplatin
目录号:
HY-16325A
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