2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. NMDI14

NMDI14 是一种无义介导的 RNA 衰变 (NMD) 抑制剂。NMDI14干扰SMG7-UPF1相互作用，抑制无义介导的 RNA 衰变。

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NMDI14 Chemical Structure

NMDI14 Chemical Structure

CAS No. : 307519-88-6

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥905
In-stock
1 mg ￥342
In-stock
5 mg ￥900
In-stock
10 mg ￥1440
In-stock
25 mg ￥2880
In-stock
50 mg ￥4360
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

NMDI14 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. NMDI14 disrupts the SMG7-UPF1 interactions and inhibits NMD.

IC50 & Target

NMD[1]
体外研究
(In Vitro)

NMDI14 is a nonsense mediated RNA decay (NMD) inhibitor. Treating cells with NMDI14 for 6 hours leads to an increase of PTC 39 β globin to 12%, a relative four-fold increase that, if resulting in biologically active hemoglobin, would be sufficient to ameliorate the clinical symptoms of thalassemia. Three days of treatment with NMDI14 results in no decrease in cell counts, demonstrating that the pharmacological inhibition of NMD can be achieved without subtle changes in proliferation. 941 genes are increased >1.5 fold with NMDI14. The treatment of N417 cells with NMDI14 for 6 hours leads to a steady state expression of p53 similar to that seen in U2OS cells. NMDI14 significantly increases the stability of PTC mutated p53 mRNA in N417 cells, without altering the stability of wild-type p53 in NMDI-treated U2OS cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NMDI14 相关抗体:
分子量

415.51

Formula

C21H25N3O4S
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (24.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.4067 mL 12.0334 mL 24.0668 mL
5 mM 0.4813 mL 2.4067 mL 4.8134 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.68%

COA (287 KB) HNMR (312 KB) RP-HPLC (255 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

To assess viability cells are cultured in 6 well dishes and incubated with DMSO, G418, NMDI alone or G418 with NMDI together for the indicated hours. After incubations, cells and media are collected and cells viability is measured. To assess cell proliferation U2OS, Hela and BJ-htert cells are cultured in 6 well plates and, after 24 hrs, treated with NMDI14 for 0, 24, 48 and 72hrs. The cells are collected and viable cells are counted by using the Countess Automated Cell Counter[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

NMDI14 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4067 mL 12.0334 mL 24.0668 mL 60.1670 mL
5 mM 0.4813 mL 2.4067 mL 4.8134 mL 12.0334 mL
10 mM 0.2407 mL 1.2033 mL 2.4067 mL 6.0167 mL
15 mM 0.1604 mL 0.8022 mL 1.6045 mL 4.0111 mL
20 mM 0.1203 mL 0.6017 mL 1.2033 mL 3.0084 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMDI14307519-88-6NMDI 14NMDI-14DNA/RNA SynthesisInhibitorinhibitorinhibit

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目录号：
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