2. Anti-infection
  3. HIV
  4. beta-L-D4A

beta-L-D4A  (Synonyms: 2'3'-didehydro-2'3'-dideoxyadenosine)

目录号: HY-100260
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beta-L-D4A 是一个核苷类型的 HIV-1 逆转录酶抑制剂。

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beta-L-D4A

beta-L-D4A Chemical Structure

CAS No. : 7057-48-9

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规格 价格 是否有货 数量
1 mg ￥1500
1 - 2 周
5 mg ￥3750
1 - 2 周
10 mg ￥6000
1 - 2 周
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

beta-L-D4A 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor.

IC50 & Target

HIV-1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C3H CC50
> 100 μM
Compound: 2[d4A]
Compound was evaluated cytotoxicity against moloney sarcoma virus (MSV) infected C3H cell cultures.
Compound was evaluated cytotoxicity against moloney sarcoma virus (MSV) infected C3H cell cultures.
10.1016/0960-894X(96)00433-7
C3H/3T3 EC50
35 μM
Compound: 3
Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts
Effect of compound against Moloney murine sarcoma virus (MSV)-induced transformation of C3H/3T3 embryo murine fibroblasts
[PMID: 10229629]
CCRF-CEM CC50
360.3 μM
Compound: 2, d4A
Cytotoxicity against human CEM/0 cells
Cytotoxicity against human CEM/0 cells
[PMID: 24411122]
CCRF-CEM CC50
91 μM
Compound: 2[d4A]
Compound was evaluated for cytotoxic activity against CEM cells.
Compound was evaluated for cytotoxic activity against CEM cells.
10.1016/0960-894X(96)00433-7
CCRF-CEM CC50
91 μM
Compound: d4A
Compound was evaluated for its concentration (potency) to inhibit the growth of CEM cells.
Compound was evaluated for its concentration (potency) to inhibit the growth of CEM cells.
[PMID: 10498207]
CCRF-CEM CC50
96 μM
Compound: 3
In vitro cytotoxic concentration in CEM cells.
In vitro cytotoxic concentration in CEM cells.
[PMID: 10229629]
CCRF-CEM EC50
0.54 μM
Compound: 7 beta-Ld4A
Antiviral activity against HIV in CEM cell line
Antiviral activity against HIV in CEM cell line
10.1016/0960-894X(96)00293-4
CCRF-CEM EC50
20 μM
Compound: 2[d4A]
Compound was evaluated for antiviral activity against HIV-1 (IIIB) infected CEM cells.
Compound was evaluated for antiviral activity against HIV-1 (IIIB) infected CEM cells.
10.1016/0960-894X(96)00433-7
CCRF-CEM EC50
20 μM
Compound: 2[d4A]
Compound was evaluated for antiviral activity against HIV-2 (ROD) infected CEM cells.
Compound was evaluated for antiviral activity against HIV-2 (ROD) infected CEM cells.
10.1016/0960-894X(96)00433-7
CCRF-CEM EC50
20 μM
Compound: d4A
Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-1 in CEM cell culture.
Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-1 in CEM cell culture.
[PMID: 10498207]
CCRF-CEM EC50
20 μM
Compound: d4A
Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-2 in CEM cell culture.
Compound was evaluated for its effective concentration (potency) to inhibit the growth of HIV-2 in CEM cell culture.
[PMID: 10498207]
CCRF-CEM IC50
37 μM
Compound: 7 beta-Ld4A
Concentration required to inhibit 50% of CEM cell lines
Concentration required to inhibit 50% of CEM cell lines
10.1016/0960-894X(96)00293-4
CCRF-CEM IC50
>= 81.9 μM
Compound: 2, d4A
Antiviral activity against HIV-2 ROD infected in thymidine kinase-deficient human CEM cells
Antiviral activity against HIV-2 ROD infected in thymidine kinase-deficient human CEM cells
[PMID: 24411122]
HepG2 EC50
1.2 μM
Compound: 7 beta-Ld4A
Antiviral activity against Hepatitis B virus in 2.2.15 cell line
Antiviral activity against Hepatitis B virus in 2.2.15 cell line
10.1016/0960-894X(96)00293-4
HepG2 IC50
70 μM
Compound: 7 beta-Ld4A
Concentration required to inhibit 50% of 2.2.15 cell line
Concentration required to inhibit 50% of 2.2.15 cell line
10.1016/0960-894X(96)00293-4
MT4 CC50
277.5 μM
Compound: 2, d4A
Cytotoxicity against human MT4 cells
Cytotoxicity against human MT4 cells
[PMID: 24411122]
MT4 ED50
> 25 μM
Compound: 18
Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction
Anti-HIV activity was determined as dose required to protect 50% of the HIV-infected MT-4 cells against destruction
[PMID: 3499515]
MT4 IC50
> 277.5 μM
Compound: 2, d4A
Antiviral activity against HIV-1 3B infected in human MT4 cells
Antiviral activity against HIV-1 3B infected in human MT4 cells
[PMID: 24411122]
MT4 IC50
> 277.5 μM
Compound: 2, d4A
Antiviral activity against HIV-2 ROD infected in human MT4 cells
Antiviral activity against HIV-2 ROD infected in human MT4 cells
[PMID: 24411122]
体外研究
(In Vitro)

beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. Results confirm that the biological activity of NSC 108602 is connected with the termination of the DNA chain synthesis in the 5′-3′ direction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

beta-L-D4A 相关抗体:
分子量

233.23

Formula

C10H11N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

beta-L-D4A 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

beta-L-D4A7057-48-92'3'-didehydro-2'3'-dideoxyadenosineHIVHuman immunodeficiency virusInhibitorinhibitorinhibit

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