1. GPCR/G Protein
  2. Protease Activated Receptor (PAR)
  3. PAR-4 Agonist Peptide, amide

PAR-4 Agonist Peptide, amide  (Synonyms: PAR-4-AP; AY-NH2)

目录号: HY-P1309 纯度: 99.48%
COA 产品使用指南

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) 是一种蛋白酶激活受体-4 (PAR-4) 激动剂,对 PAR-1 或 PAR-2 都没有作用,且其作用会被 PAR-4 拮抗剂阻断。

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Custom Peptide Synthesis

PAR-4 Agonist Peptide, amide Chemical Structure

PAR-4 Agonist Peptide, amide Chemical Structure

CAS No. : 352017-71-1

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥600
In-stock
5 mg ¥1800
In-stock
10 mg ¥3000
In-stock
50 mg   询价  
100 mg   询价  

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MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist.

IC50 & Target

PAR4

 

体内研究
(In Vivo)

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

680.79

Formula

C34H48N8O7

CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

AYPGKF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (146.89 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4689 mL 7.3444 mL 14.6888 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
SCID mice Male SCID mice and their BALB/cBy controls are operated as C57BL/6J mice, and on the 4th postoperative day mice receive intracolonically (IC) infusion of 100 μg PAR-4-AP or vehicle. Visceral pain measurements started 1 h following the end of infusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

PAR-4 Agonist Peptide, amide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4689 mL 7.3444 mL 14.6888 mL 36.7220 mL
5 mM 0.2938 mL 1.4689 mL 2.9378 mL 7.3444 mL
10 mM 0.1469 mL 0.7344 mL 1.4689 mL 3.6722 mL
15 mM 0.0979 mL 0.4896 mL 0.9793 mL 2.4481 mL
20 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8361 mL
25 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4689 mL
30 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2241 mL
40 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
50 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
60 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
80 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.4590 mL
100 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
PAR-4 Agonist Peptide, amide
目录号:
HY-P1309
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