2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. RCM-1

RCM-1 是一种 forkhead box M1 (FOXM1) 抑制剂，在 U2OS 细胞中的 EC50 为 0.72 μM。RCM-1 阻止了核定位并增加了 FOXM1 的蛋白酶体降解。RCM-1 可用于哮喘和其他慢性气道疾病的研究。

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RCM-1

RCM-1 Chemical Structure

CAS No. : 339163-65-4

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1100
In-stock
1 mg ￥500
In-stock
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3200
In-stock
50 mg ￥5120
In-stock
100 mg 现货 询价
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

RCM-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC50 of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research[1].

IC50 & Target

FOXM1[1].
体外研究
(In Vitro)

RCM-1 可阻断 FOXM1 (一种对气道祖细胞分化为杯状细胞至关重要的转录因子) 的核定位，并增加其蛋白酶体降解。在培养的气道上皮细胞中，RCM-1 可降低 IL-13 和 STAT6 信号传导，并阻止 STAT6 靶基因 Spdef 和 Foxa3 的表达，这些基因是杯状细胞分化的关键转录调节因子[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RCM-1 相关抗体:
体内研究
(In Vivo)

RCM-1 可降低暴露于屋尘螨和白细胞介素-13 (IL-13) 的小鼠的气道阻力，增加肺顺应性，并减少促炎细胞因子的产生，IL-13 可引发杯状细胞化生。在小鼠中，RCM-1 可降低 IL-13 和 STAT6 信号传导，并阻止 STAT6 靶基因 Spdef 和 Foxa3 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

424.58

Formula

C20H12N2OS4
CAS 号
性状

固体

颜色

Off-white to gray

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (39.26 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3553 mL 11.7763 mL 23.5527 mL
5 mM 0.4711 mL 2.3553 mL 4.7105 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.56%

COA (291 KB) LCMS (89 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

Rd76-9 rhabdomyosarcoma, B16-FlO melanoma, H2122 lung adenocarcinoma, 4T1 breast carcinoma, MyC-CaP prostate carcinoma and KPC-2 pancreatic carcinoma cells are seeded in 6-well plates and incubated overnight. The cells are treated with 20 μM concentration of RCM-1 for 24, 48 and 72 h and cell growth is analyzed by counting alive cells using trypan blue. Cells treated with DMSO are used as controls[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Administration
[1]

Mice[1]
Mouse Rd76-9 rhabdomyosarcoma cells (1×106 cells) are injected intramuscularly in the flanks of C56Bl/6J mice (n=8 mice per group). Seven days after the tumor cells inoculation, 40 μL of either Vehicle (DMSO) or RCM-1 (20 mg/kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 16. RCM-1 treatment decreases Rd76-9 tumor growth as compared to the DMSO-treated group. Mouse B 16-FlO melanoma cells (1×106 cells) are injected subcutaneously in C56Bl/6J mice (n=7 animals per group). Three days after the tumor cell inoculation, 40 μL of either Vehicle (DMSO) or RCM1 (20 mg/Kg body weight) are injected intraperitoneally in the animals every other day. The animals are sacrificed and tumors are harvested on day 12[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

RCM-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3553 mL 11.7763 mL 23.5527 mL 58.8817 mL
5 mM 0.4711 mL 2.3553 mL 4.7105 mL 11.7763 mL
10 mM 0.2355 mL 1.1776 mL 2.3553 mL 5.8882 mL
15 mM 0.1570 mL 0.7851 mL 1.5702 mL 3.9254 mL
20 mM 0.1178 mL 0.5888 mL 1.1776 mL 2.9441 mL
25 mM 0.0942 mL 0.4711 mL 0.9421 mL 2.3553 mL
30 mM 0.0785 mL 0.3925 mL 0.7851 mL 1.9627 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RCM-1339163-65-4RCM1RCM 1DNA/RNA SynthesisInhibitorinhibitorinhibit

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目录号：
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