2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid  (Synonyms: DGLA; all-cis-8,11,14-Eicosatrienoic acid)

目录号: HY-A0143 纯度: ≥99.0%
COA 产品使用指南 技术支持

Dihomo-γ-linolenic acid (DGLA) 是 20 个碳的 ω-6 脂肪酸，具有抗炎和抗增殖活性。Dihomo-γ-linolenic acid 能减弱载脂蛋白 E 缺陷小鼠模型模型的动脉粥样硬化。

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Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid Chemical Structure

CAS No. : 1783-84-2

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规格 价格 是否有货 数量
5 mg (326.28 mM * 50 μL in Ethanol) ￥800
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Other Forms of Dihomo-γ-linolenic acid:

Dihomo-γ-linolenic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
RBL-2H3 IC50
> 50 μM
Compound: 4
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
Antiallergic activity in rat RBL2H3 cells assessed as inhibition of DNP-HSA-mediated degranulation by measuring decrease in beta-hexosaminidase activity preincubated for 30 mins followed by DNP-HSA stimulation and measured after 30 mins by 4-nitrophenyl 2
[PMID: 31618024]
体外研究
(In Vitro)

Dihomo-γ-linolenic acid 可减弱人类和小鼠巨噬细胞中的促炎基因表达[2]。
Dihomo-γ-linolenic acid (50 μM；24 小时) 可减弱 IFN-γ 诱导的 STAT1 在丝氨酸 727 上的磷酸化[2]。
Dihomo-γ-linolenic acid 可减弱 IL-1β 和 TNF-α 诱导的人类巨噬细胞中的 MCP-1 和 ICAM-1 表达[2]。
Dihomo-γ-linolenic acid 可减弱趋化因子驱动的单核细胞迁移和巨噬细胞泡沫细胞形成[2]。
Dihomo-γ-linolenic acid 可减弱人类巨噬细胞[2]。
Dihomo-γ-linolenic acid 调节线粒体呼吸[2]。
Dihomo-γ-linolenic acid 调节内皮细胞和平滑肌细胞 (VSMC) 的特性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Dihomo-γ-linolenic acid 相关抗体:

Western Blot Analysis[2]

Cell Line: THP-1 macrophages
Concentration: 50 μM (pre-treated)
Incubation Time: 24 hours
Result: Attenuated IFN-γ induced phosphorylation of STAT1 on serine 727.
体内研究
(In Vivo)

Dihomo-γ-linolenic acid (8 mg/只小鼠；肠内注射；每周两次；持续 35 天)可抑制携带转染了 delta-5-去饱和酶 shRNA 的人类胰腺癌细胞 (BxPC-3) 的小鼠中异种移植肿瘤的生长[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (48 four-week old)[3]
Dosage: 8 mg/mouse
Administration: Oral gavage, twice a week, for 35 days
Result: Suppressed metastasis potential in D5D-KD tumors.
分子量

306.48

Formula

C20H34O2
CAS 号
性状

液体

颜色

Colorless to light yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

COA (275 KB)

产品使用指南 (1538 KB)
参考文献

Dihomo-γ-linolenic acid 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dihomo-γ-linolenic acid1783-84-2DGLA all-cis-8,11,14-Eicosatrienoic acidEndogenous Metaboliteanti-inflammatoryanti-proliferativefattyacidatherosclerosisInhibitorinhibitorinhibit

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