1. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  2. Reactive Oxygen Species (ROS)
  3. Albendazole-d3-1

Albendazole-d3-1  (Synonyms: SKF-62979-d3-1)

目录号: HY-B0223S4
产品使用指南 技术支持

Albendazole-d3-1 (SKF-62979-d3-1) 是 Albendazole (HY-B0223) 的氘代物。Albendazole (SKF-62979) 是一种口服有效的广谱的抗寄生虫剂,具有高效、低宿主毒性的特点,可用于人类和动物胃肠道寄生虫的研究。Albendazole 可诱导癌细胞的凋亡和自噬,并抗细胞增殖和抑制细胞周期进程。Albendazole 还能抑制微管蛋白的聚合和 HIF-1αVEGF 的表达,具有抗氧化活性,能抑制癌细胞的糖酵解过程。

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Albendazole-d<sub>3</sub>-1 Chemical Structure

Albendazole-d3-1 Chemical Structure

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  • 生物活性

  • 纯度 & 产品资料

生物活性

Albendazole-d3-1 (SKF-62979-d3-1) is the deuterium labeled Albendazole (HY-B0223). Albendazole (SKF-62979) is an orally active and broad-spectrum parasiticide with high effectiveness and low host toxicity, is used for the research of gastrointestinal parasites in humans and animals. Albendazole induces apoptosis and autophagy in cancer cells. Albendazole also inhibits tubulin polymerization and HIF-1α, VEGF expression, has antioxidant activity, and inhibits the glycolytic process in cancer cells[1][2][3][4][5].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

268.35

Formula

C12H12D3N3O2S

非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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