2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. AMG8380

AMG8380 是一种具有口服活性的和低活性的 AMG8379 的对映体，可作为阴性对照。AMG8380 抑制人和小鼠电压门控钠通道 NaV1.7，IC50 分别为 0.907、0.387 μM。AMG8380 阻断 Tetrodotoxin 敏感的通道用 IC50 为 2560 nM。

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AMG8380 Chemical Structure

AMG8380 Chemical Structure

CAS No. : 1642112-32-0

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AMG8380 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1].

IC50 & Target[1]

hNav1.7

0.907 μM (IC50)

mNav1.7

0.387 μM (IC50)

体内研究
(In Vivo)
Animal Model: C57Bl/6 male mice[1]
Dosage: 100 mg/kg
Administration: oral
Result: Failed to show a statistically significant effect on scratching behavior.
分子量

543.93

Formula

C25H16ClF2N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMG8380 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG83801642112-32-0AMG 8380AMG-8380Sodium ChannelNa channelsNa+ channelsoralenantiomersulfonamidescratchingbehaviornociceptivepainitchInhibitorinhibitorinhibit

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产品名称：
AMG8380
目录号：
HY-108425A
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