2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. AMP-PCP

AMP-PCP 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP 结合有利于 Hsp90 活性同型二聚体的形成。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 AMP-PCP disodium 通常具有更好的水溶性和稳定性。

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AMP-PCP Chemical Structure

AMP-PCP Chemical Structure

CAS No. : 3469-78-1

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AMP-PCP 的其他形式现货产品:

Customer Review

Other Forms of AMP-PCP:

AMP-PCP 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

IC50 & Target[1]

HSP90

3.8 μM (Kd)

体外研究
(In Vitro)

AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMP-PCP 相关抗体:
分子量

505.21

Formula

C11H18N5O12P3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMP-PCP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMP-PCP3469-78-1HSPHeat shock proteinsATPhomodimerHsp90residuesconformationalN-terminalATPaseInhibitorinhibitorinhibit

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