2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease PI3K/Akt/mTOR Immunology/Inflammation
  3. HSP Akt Interleukin Related
  4. Anti-Human/Mouse GRP78 Antibody (N88)

Anti-Human/Mouse GRP78 Antibody (N88) 

目录号: HY-P990239
技术支持

Anti-Human/Mouse GRP78 Antibody (N88) 是一种抗人/鼠 GRP78 IgG1 单克隆抗体。Anti-Human/Mouse GRP78 Antibody (N88) 可以激活 Akt 信号通路。Anti-Human/Mouse GRP78 Antibody (N88) 可以抑制 TLR 激动剂诱导的炎症因子和纤溶酶原激活物抑制剂的表达。Anti-Human/Mouse GRP78 Antibody (N88) 可用于研究炎症疾病。Anti-Human/Mouse GRP78 Antibody (N88) 可用于免疫沉淀。

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Anti-Human/Mouse GRP78 Antibody (N88)

Anti-Human/Mouse GRP78 Antibody (N88) Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Anti-Human/Mouse GRP78 Antibody (N88) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation[1][2].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Human/Mouse
IC50 & Target[1]

IL-6

 

IL-1β

 

体外研究
(In Vitro)

Anti-Human/Mouse GRP78 Antibody (N88) (1 μg/mL，1 小时或 6 小时) 显著抑制骨髓源性巨噬细胞 (BMDMs) 中 LPS (HY-D1056) 诱导的 TNF α、IL-6、IL-1β、CCL2、CCL3 和 CCL4 的表达，并降低 IκBα 的磷酸化[1]。
Anti-Human/Mouse GRP78 Antibody (N88) (1 μg/mL，1 小时或 6 小时) 广泛抑制 BMDM 中多种 TLR 激动剂 (Lipoteichoic acid (LTA) (HY-N9481)、Imiquimod (IMQ) (HY-B0180) 或 ODN 1826 (HY-146245)) 诱导的炎症反应和 PAI1 和 PAI2 的表达[1]。
Anti-Human/Mouse GRP78 Antibody (N88) (1 μg/mL，15 分钟) 以剂量依赖的方式激活 B16F1 细胞中的 Akt 磷酸化。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Mouse GRP78 Antibody (N88) 相关抗体:

RT-PCR[1]

Cell Line: BMDMs
Concentration: 1 μg/mL, or co-incubation with LTA (1 μg/mL), IMQ (3 μg/mL) or ODN 1826 (1 μg/mL)
Incubation Time: 6 h
Result: Significantly reduced the mRNA level of TNF α, IL-6, IL-1β, CCL2, CCL3, and CCL4.

Western Blot Analysis[1]

Cell Line: BMDMs
Concentration: 1 μg/mL, or co-incubation with LTA (1 μg/mL), IMQ (3 μg/mL) or ODN 1826 (1 μg/mL)
Incubation Time: 1 h
Result: Reduced the phosphorylation of IκBα.

RT-PCR[1]

Cell Line: BMDMs
Concentration: 1 μg/mL, or co-incubation with LTA (1 μg/mL), IMQ (3 μg/mL) or ODN 1826 (1 μg/mL)
Incubation Time: 1 h
Result: Reduced the mRNA level of PAI1 and PAI2.
体内研究
(In Vivo)

Anti-Human/Mouse GRP78 Antibody (N88) (200 μg，腹腔注射，每 14 天一次) 加速了携带 B16F1 肿瘤的雌性 C57BL/6 小鼠的肿瘤生长并缩短了存活时间[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5000 B16F1 cells injected female C57BL/6 mice (4-6 weeks)[3]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), once every 14 days
Result: Significantly accelerated tumor growth.
Shortened median survival to 19 days.
基因 ID

14828  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Human/Mouse GRP78 Antibody (N88) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Mouse GRP78 Antibody (N88)HSPAktInterleukin RelatedHeat shock proteinsPKBProtein kinase BILGRP78TLR agonistsinflammationimmunoprecipitationB16F1Inhibitorinhibitorinhibit

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