Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) 

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a rat-derived IgG2a κ antibody inhibitor, targeting to mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can block 4-1BB ligand (4-1BBL) and inhibit CD4⁺ and CD8⁺ T cells. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) can be used for the researches of cancer, infection, inflammation and immunology, such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection and herpetic stromal keratitis (HSK)^{[1][2][3][4][5]}.

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

4-1BBL/CD137L

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (5 μg/mL or 50 μg/mL, 3 days) 抑制 CD4⁺和 CD8⁺ T 细胞针对同种异体抗原呈递细胞的增殖，并降低 Balb/c 抗原呈递细胞刺激的正常 C57BL/6 T 细胞对宿主同种异体抗原的细胞毒性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (150 μg，腹腔注射，感染的前 1 天及感染后第 1 和 3 天给药) 与抗 OX40L (HY-P990175) 联合使用，可减弱淋巴细胞性脉络丛脑膜炎病毒 (LCMV) 感染的 Cd70/80/86^−/−小鼠中 LCMV 特异性 CD8⁺ T 细胞反应的强度^[1]。
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg，腹腔注射，在第 0、3、6 和 8 天给药) 可抑制单纯疱疹病毒 1 型 RE 株感染的疱疹性基质性角膜炎 (HSK) 小鼠中 HSK 的发展^[2]。
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (200 μg，腹腔注射，在第 0、2 和 4 天给药) 可延长 Balb/c 心脏移植的 C57BL/6 小鼠中的移植物存活时间^[3]。
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg/25g，腹腔注射，在应用 IMQ 前每日给药) 可减轻咪喹莫特 (IMQ) (HY-B0180) 诱导的银屑病小鼠的炎症^[4]。
Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) (100 μg，腹腔注射，在第 0 和 2 天给药) 与 3H3 (HY-P99119) 抗体联合使用，可抑制 MC38 肿瘤小鼠的肿瘤生长^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

21950  [NCBI]

P41274

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Welten SP, et al. The viral context instructs the redundancy of costimulatory pathways in driving CD8(+) T cell expansion. Elife. 2015 Aug 11;4:e07486.  [Content Brief]

  [2]. Seo SK, et al. Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. J Immunol. 2003 Jul 15;171(2):576-83.  [Content Brief]

  [3]. Cho HR, et al. Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival. Transpl Int. 2004 Aug;17(7):351-61.  [Content Brief]

  [4]. Miki H, et al. 4-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis. J Immunol. 2020 Apr 1;204(7):1892-1903.  [Content Brief]

  [5]. Cho E, et al. 4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8+ T cell. Cell Mol Immunol. 2023 Sep;20(9):1077-1080.  [Content Brief]