2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 

目录号: HY-P990221
技术支持

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 是一种小鼠源 IgG1 κ 型抗体抑制剂，靶向小鼠 IL-17F。Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 可中和 IL-17。Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 可用于癌症、感染和神经疾病的研究，如阿尔茨海默病 (AD) 和胰腺癌。

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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Chemical Structure

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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17F. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can neutralize IL-17. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can be used for the researches of cancer, infection and neurological disease, such as Alzheimer’s disease (AD) and pancreatic cancer[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IL-17F
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (第一天 200 μg，此后每隔一天 100 μg，腹腔注射，持续 3 周) 可恢复阿尔茨海默病小鼠的神经退行性小胶质细胞反应和认知能力[1]。
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (400 μg，腹腔注射，每 3-4 天一次，直至 6 周) 可减轻胰腺癌小鼠模型的疾病负担和病理性纤维化[2]。
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (前一天给药 200 μg，此后每隔一天 100 μg，腹腔注射) 与抗 IL-17A (HY-P990222) 联用，在金黄色葡萄球菌感染的小鼠模型中显示出抗感染作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alzheimer’s disease mice models[1]
Dosage: 200 μg for the first day and 100 μg every other day
Administration: Intraperitoneally injection, 3 weeks
Result: Reduced neutrophil recruitment and proportion of γδ T cells.
Increased proportion of phagocytic microglia.
Reduced IL-17, IL-8 and TGFβ signaling in non-phagocytic microglia and neutrophil degranulation in phagocytic microglia.
Reduced accumulation of neutrophils at the choroid plexus.
Increased immunoreactivity of Clec7a+ neurodegenerative microglia.
Animal Model: S. aureus infected mice models[3]
Dosage: 200 μg at days −1 and 100 μg every other day thereafter
Administration: Intraperitoneally injection, companied with anti-IL-17A (HY-P990222)
Result: Resulted in statistically increased lesion sizes and in vivo BLI signals.
基因 ID

257630  [NCBI]

Accession

Q7TNI7-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)Interleukin RelatedILIL-17Alzheimer’s diseasePancreatic cancerS. aureusMicrogliaInhibitorinhibitorinhibit

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