2. Immunology/Inflammation
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  4. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 

目录号: HY-P990221 纯度: ≥95.0%
COA 技术支持

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 是一种小鼠源 IgG1 κ 型抗体抑制剂，靶向小鼠 IL-17F。Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 可中和 IL-17。Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 可用于癌症、感染和神经疾病的研究，如阿尔茨海默病 (AD) 和胰腺癌。

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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Chemical Structure

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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17F. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can neutralize IL-17. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can be used for the researches of cancer, infection and neurological disease, such as Alzheimer’s disease (AD) and pancreatic cancer[1][2][3].

同型

Mouse IgG1 kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

IL-17F
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (第一天 200 μg，此后每隔一天 100 μg，腹腔注射，持续 3 周) 可恢复阿尔茨海默病小鼠的神经退行性小胶质细胞反应和认知能力[1]。
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (400 μg，腹腔注射，每 3-4 天一次，直至 6 周) 可减轻胰腺癌小鼠模型的疾病负担和病理性纤维化[2]。
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (前一天给药 200 μg，此后每隔一天 100 μg，腹腔注射) 与抗 IL-17A (HY-P990222) 联用，在金黄色葡萄球菌感染的小鼠模型中显示出抗感染作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Alzheimer’s disease mice models[1]
Dosage: 200 μg for the first day and 100 μg every other day
Administration: Intraperitoneally injection, 3 weeks
Result: Reduced neutrophil recruitment and proportion of γδ T cells.
Increased proportion of phagocytic microglia.
Reduced IL-17, IL-8 and TGFβ signaling in non-phagocytic microglia and neutrophil degranulation in phagocytic microglia.
Reduced accumulation of neutrophils at the choroid plexus.
Increased immunoreactivity of Clec7a+ neurodegenerative microglia.
Animal Model: S. aureus infected mice models[3]
Dosage: 200 μg at days −1 and 100 μg every other day thereafter
Administration: Intraperitoneally injection, companied with anti-IL-17A (HY-P990222)
Result: Resulted in statistically increased lesion sizes and in vivo BLI signals.
基因 ID

257630  [NCBI]

Accession

Q7TNI7-1
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)Interleukin RelatedILIL-17Alzheimer’s diseasePancreatic cancerS. aureusMicrogliaInhibitorinhibitorinhibit

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