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  2. 一抗
  3. 单克隆抗体 重组抗体
  4. Activin Receptor Type IA 抗体 (YA1994)

Activin Receptor Type IA 抗体 (YA1994)

目录号: HY-P82249
COA 抗体使用指南 技术支持

Activin Receptor Type IA Antibody (YA1994) 是一个兔来源、无偶联标记、抗 Activin Receptor Type IA 的 IgG 单克隆抗体。

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规格 价格 是否有货 数量
10 μL ¥470 In-stock
50 μL ¥1220 In-stock
100 μL ¥2000 In-stock
250 μL   询价  

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【WB: 蛋白质免疫印迹; IHC-P: 石蜡切片样本的免疫组织化学; IHC-F: 冰冻切片样本的免疫组织化学; ICC/IF: 细胞免疫荧光; IF-Tissue: 组织免疫荧光; mIHC: 多重荧光免疫组化; IP: 免疫沉淀; ChIP: 染色质免疫沉淀; FC: 流式细胞术; ELISA: 酶联免疫吸附试验】

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

Activin Receptor Type IA Antibody (YA1994) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Activin Receptor Type IA.

研究背景

Activin Receptor Type IA(ACVR1)是一种骨形态发生蛋白(BMP)I 型受体,参与骨骼、心脏、软骨、神经及生殖系统发育等多种生物学过程。作为 I 型受体,它与 II 型受体(AMHR2、ACVR2A 或 ACVR2B)形成异源四聚体复合物,在结合 BMP7 或 GDF2/BMP9 等配体后,被 II 型受体反式磷酸化激活,进而磷酸化 SMAD1/5/8 介导 BMP 信号通路(by similar:可能通过 p38 MAPK 激活非经典通路)。此外,ACVR1 还能通过干扰 activin 与 II 型受体的结合来抑制 TGFβ/activin 通路信号(by similar:可能与 BMP6 相互作用促进 HAMP 表达)。

基因 ID
蛋白数据库
中文名
Activin Receptor Type IA 抗体 (YA1994)
同用名
ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
分子量

Predicted band size: 57 kDa; Observed band size: 57 kDa

纯度

Affinity Purified

偶联

Non-conjugated

修饰

Unmodified

研究领域

Signal Transduction

产品类别

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

克隆性

Recombinant, Monoclonal

宿主

Rabbit

反应物种

Human, Mouse

推荐稀释比例

WB: 1/500-1/1000;IP: 1/20

  • Western blot analysis was performed on extracts from Mouse brain (lane 1, 15 μg), Rat brain (lane 2, 15 μg), and Mouse heart (lane 3, 15 μg) using Activin Receptor Type IA Rabbit mAb.Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST at 4°C overnight.The primary antibody (1:1000 dilution) and the loading control antibody (GAPDH, HY-P80137, 1:60000 dilution) were incubated in 5% non-fat milk in TBST for 1 hour at 37°C.Goat Anti-Rabbit IgG-HRP Secondary Antibody (1:20000 dilution) was then applied for 40 minutes at 37°C.
应用

WB, IP

性状

液体

组分

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

保存条件 & 期限

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

运输条件

Shipping with blue ice.

同型

IgG

敏感性

Endogenous

免疫原

A synthetic peptide of human Activin Receptor Type IA

数据库
文件资料

Activin Receptor Type IA Antibody (YA1994) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Activin Receptor Type IA Antibody (YA1994)
目录号:
HY-P82249
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