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  2. Apelin-12

Apelin-12 

目录号: HY-P2537
产品使用指南

Apelin-12 是多肽中最有效的 C 端片段之一,对孤儿受体 APJ 受体具有很高的亲和力。Apelin-12 参与体液平衡的调节和摄食的中枢控制。Apelin-12 阻断HIV-1通过 APJ 受体进入。Apelin-12 具有神经保护作用。

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Apelin-12 Chemical Structure

Apelin-12 Chemical Structure

CAS No. : 229961-08-4

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Description

Apelin-12 is one of the most potent C-terminal fragments of the polypeptide that possesses a high affinity to orphan receptor APJ receptor. Apelin-12 is involved in the regulation of body fluid homeostasis and in the central control of feeding. Apelin-12 blocks HIV-1 entry through APJ receptor. Apelin-12 exerts neuroprotective effect[1][2][3].

In Vitro

Apelin-12 (A12) exerts neuroprotective effect against ischemia-reperfusion injury by inhibiting JNK and p38 MAPK signaling pathway in mouse[1].
Administration of exogenous A12 reduces arterial blood pressure in anesthetized rats due to activation of endothelial nitric oxide synthase and exerts a positive inotropic action in failing myocardium of rodents[2].
Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs[4].

Molecular Weight

1422.70

Formula

C₆₄H₁₀₃N₂₁O₁₄S

CAS No.

229961-08-4

Sequence Shortening

RPRLSHKGPMPF

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Apelin-12Apelin12Apelin 12OthersorphanreceptorbodyfluidhomeostasisneuroprotectivehistamineacidsecretionInhibitorinhibitorinhibit

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产品名称:
Apelin-12
目录号:
HY-P2537
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