2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Reactive Oxygen Species
  4. Argininosuccinic acid

Argininosuccinic acid 参与尿素循环的第四步，被精氨酸琥珀酸裂解酶 (ASL) 裂解为精氨酸和富马酸。Argininosuccinic acid 降低还原型谷胱甘肽 (GSH) 浓度，增加大脑皮层和纹状体的活性氧生成。Argininosuccinic acid 可引起脂质过氧化和蛋白质氧化，还在发育中大鼠脑中诱导氧化应激。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Argininosuccinic acid Chemical Structure

Argininosuccinic acid Chemical Structure

CAS No. : 2387-71-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Argininosuccinic acid 的其他形式现货产品:

Customer Review

Other Forms of Argininosuccinic acid:

Argininosuccinic acid 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain[1][2].

体外研究
(In Vitro)

Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层[1]。
Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度[1]。
Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Argininosuccinic acid 相关抗体:
体内研究
(In Vivo)

Argininosuccinic acid (2 μM, 2 μL; 头部注射; 单剂量) 能显著诱导 30 日龄大鼠的氧化应激[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-day-old rats with two small holes drilled in the skull[1]
Dosage: 2 μL of a 1.0 M concentration (2 μmol in 2 μL)
Administration: Injection; euthanized 2 h after treatment
Result: Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).
Significantly decreased GSH concentrations.
分子量

290.27

Formula

C10H18N4O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Argininosuccinic acid 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argininosuccinic acid2387-71-5Endogenous MetaboliteReactive Oxygen SpeciesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Argininosuccinic acid
目录号：
HY-113149
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z