1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Atibuclimab

Atibuclimab  (Synonyms: 阿替布利单抗; IC14)

目录号: HY-P99008 纯度: 99.06%
COA 技术支持

Atibuclimab (IC14) 是一种针对 CD14 的嵌合单​​克隆抗体,由鼠源可变区和人源 IgG4 Fc 区组成。Atibuclimab 可减轻 Lipopolysaccharides (HY-D1056) (LPS) 诱导的症状,并强烈抑制 LPS 诱导的促炎细胞因子释放,同时仅延缓抗炎细胞因子可溶性 TNF 受体 I 型和 IL-1 受体拮抗剂的释放。Atibuclimab 可用于研究肌萎缩侧索硬化症、脓毒症、社区获得性肺炎或急性肺损伤。

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CAS No. : 2417175-94-9

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MCE 顾客使用本产品发表的 1 篇科研文献

查看 Toll-like Receptor (TLR) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atibuclimab (IC14), is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab attenuates Lipopolysaccharides (HY-D1056) (LPS)-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist. Atibuclimab can be used for the research of amyotrophic lateral sclerosis, sepsis, community-acquired pneumonia, or acute lung injury[1][2].

IC50 & Target

CD14

体外研究
(In Vitro)

Atibuclimab (IC14) 可识别膜结合型 CD14 (mCD14) 和可溶性 CD14 (sCD14)[1]
分化簇 14 (CD14) 是一种存在于髓系细胞表面的糖蛋白。CD14 是几种 Toll 样受体 (TLR) 的辅助分子,TLR 是一个模式识别受体家族,可对与炎症和组织损伤相关的病原体和人类分子中的保守模式作出反应。 CD14 是革兰氏阴性菌和革兰氏阳性菌细胞壁成分的受体,参与脓毒症炎症反应的启动[1][2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
基因 ID

929  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

145.5 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

阿替布利单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized CD14 Protein, Human (HEK293, His, HY-P7786) can bind Atibuclimab. The EC50 for this effect is 22.13 ng/mL.
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Atibuclimab
目录号:
HY-P99008
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