2. Apoptosis
  3. IAP Apoptosis
  4. AZD5582 dihydrochloride

AZD5582 dihydrochloride 

目录号: HY-110346 纯度: 99.76%
COA 产品使用指南 技术支持

AZD5582 dihydrochloride 是 IAP 拮抗剂，可以有效与 cIAP1，cIAP2 和 XIAP 的 BIR3 结构域结合, IC50 值分别为 15，21，15 nM。AZD5582 诱导凋亡 (apoptosis)。

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AZD5582 dihydrochloride Chemical Structure

AZD5582 dihydrochloride Chemical Structure

CAS No. : 1883545-51-4

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1 mg ￥863
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5 mg ￥1900
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10 mg ￥3100
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Customer Review

Other Forms of AZD5582 dihydrochloride:

AZD5582 dihydrochloride 相关抗体

Top Publications Citing Use of Products

    AZD5582 dihydrochloride purchased from MCE. Usage Cited in: Cancer Immunol Res. 2023 Feb 8;CIR-22-0494.  [Abstract]

    AZD5582 (0.1-1 μM; 24 h) decreases the expression of cIAP1, cIAP2 and XIAP in GM-CSF DCs.

    查看 IAP 亚型特异性产品:

    查看所有亚型
    cIAP cIAP-1 cIAP-2 XIAP

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis[1].

    IC50 & Target[1]

    cIAP1

    15 nM (IC50)

    cIAP2

    21 nM (IC50)

    XIAP

    15 nM (IC50)

    体外研究
    (In Vitro)

    AZD5582 (20 nM；48 小时) 通过与 IFNγ 或病毒双链 RNA (dsRNA) 协同作用抑制 H1975 NSCLC 细胞中的细胞活力[2]。
    AZD5582 (20 nM；17 或25 小时) 下调 cIAP-1，激活 RIPK1 (caspase-8 的上游调节因子)，并触发外在 (caspase-8) 和内在 (caspase-9) 凋亡通路的激活，导致 caspase-3 和 caspase- 7 的裂解[2]。
    AZD5582 (20 nM；48 小时) 在 HCC827 NSCLC 细胞参与细胞凋亡，这是由于 AZD5582 和 IFNγ 进行联合治疗诱导细胞死亡和激活 caspase-3/8 活性所致[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    AZD5582 dihydrochloride 相关抗体:

    Cell Viability Assay[2]

    Cell Line: H1975 NSCLC cell line
    Concentration: 20 nM
    Incubation Time: 48 hours
    Result: Cooperated with IFNγ or viral double-stranded RNA (dsRNA) to inhibit cell viability even cell death.

    Apoptosis Analysis[2]

    Cell Line: HCC827 NSCLC cell line
    Concentration: 20 nM
    Incubation Time: 48 hours
    Result: Had an inhibitory effect on cell viability by cooperating with IFNγ.

    Western Blot Analysis[2]

    Cell Line: H1975 NSCLC cell line
    Concentration: 20 nM
    Incubation Time: 17 or 25 hours
    Result: Down-regulated cIAP-1, activated RIPK1 (upstream regulator of caspase-8), triggered the cleavage (activation) of caspase-3,7,8 and 9.
    体内研究
    (In Vivo)

    AZD5582 (静脉注射；0.1-3.0 mg/kg；每周一次；2周) 引起肿瘤细胞 cIAP1 降解和 caspase 3 裂解，处理两周后，肿瘤基本消退；当小鼠给予中等剂量 (0.5 mg/kg) 的 AZD5582 时，cIAP1 在给药后发生降解，但需要一段时间才能达到诱导细胞凋亡的作用[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: MDA-MB-231 xenograft-bearing mice[1]
    Dosage: 0.1 mg/kg, 0.5 mg/kg, 3.0 mg/kg
    Administration: Intravenous injection; once a week; 2 weeks
    Result: Resulted in cIAP1 degradation and caspase-3 cleavage within tumor cells and causes substantial tumor regressions following two weekly doses of 3.0 mg/kg
    分子量

    1088.21

    Formula

    C58H80Cl2N8O8
    CAS 号
    性状

    固体

    颜色

    Off-white to light yellow

    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    纯度 & 产品资料

    纯度: 99.92%

    COA (286 KB) HNMR (237 KB) LCMS (103 KB)

    产品使用指南 (1538 KB)
    参考文献

    AZD5582 dihydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AZD55821883545-51-4AZD 5582AZD-5582IAPApoptosisInhibitorinhibitorinhibit

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    目录号：
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