1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. BAY-7081

BAY-7081 是一种有效的、选择性的、具有口服活性的可溶性氰吡啶基 PDE9A 抑制剂,其 IC50 为 15 nM。

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BAY-7081 Chemical Structure

BAY-7081 Chemical Structure

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

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规格 是否有货
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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC50 of 15 nM[1].

IC50 & Target[1]

PDE9A

15 nM (IC50)

体内研究
(In Vivo)

BAY-7081 (0.3 or 1.0 mg/kg; i.v. or p.o.) 表现出良好的体内药代动力学特性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats and dogs[1]
Dosage: 0.3 or 1.0 mg/kg
Administration: Intravenous injection or oral (Pharmacokinetic Analysis)
Result: PK Profile of PDE9A Inhibitor BAY-7081 in Selected Speciesa[1]
species CLbb [L h–1 kg–1] VSSc [L kg–1] MRTd [h] Fe [%]
Rat 2.4 4.5 1.9 61
Dog 0.9 3.0 4.0 80

a Values were derived by intravenous (dose 0.3 mg/kg) and oral (dose 1.0 mg/kg) administration of solutions in either plasma 99% + DMSO 1% (rat iv) or EtOH/PEG400/H2O (dog iv, rat and dog po) vehicles.
bBlood clearance.
cVolume of distribution at steady state.
dMean residence time after iv application.
eOral bioavailability.
分子量

362.90

Formula

C19H27ClN4O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BAY-7081
目录号:
HY-152106
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