1. Epigenetics Apoptosis
  2. Histone Demethylase Apoptosis
  3. Bomedemstat

Bomedemstat  (Synonyms: IMG-7289)

目录号: HY-109169
COA 产品使用指南

Bomedemstat (IMG-7289) 是一种具有口服活性和不可逆的 lysine-specific demethylase 1 (LSD1) 抑制剂。Bomedemstat 可以增加 H3K4 和 H3K9 的甲基化,然后改变基因表达。Bomedemstat 具有抗癌活性,可抑制癌细胞增殖并诱导细胞凋亡。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 Bomedemstat dihydrochlorideBomedemstat ditosylateBomedemstat hydrochloride

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Bomedemstat Chemical Structure

Bomedemstat Chemical Structure

CAS No. : 1990504-34-1

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
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100 mg   询价  
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Customer Review

Other Forms of Bomedemstat:

查看 Histone Demethylase 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bomedemstat (IMG-7289) is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2].

体外研究
(In Vitro)

Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2V617F cells by concomitantly increasing expression and methylation of p53[1].
Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SET-2 cells
Concentration: 50 nM, 100 nM, and 1 μM
Incubation Time: 96 hours
Result: Decreased levels of the antiapoptotic protein BCL-XL and increased levels of the pro-apoptotic protein PUMA.
体内研究
(In Vivo)

Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mx-Jak2V617F mice[1]
Dosage: 45 mg/kg
Administration: Oral gavage; 45 mg/kg; once daily; 56 days
Result: Reduced splenomegaly significantly with a few treated mice normalizing their spleen weight, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.
Clinical Trial
分子量

519.61

Formula

C28H34FN7O2

CAS 号
性状

油状物

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验: 

DMSO 中的溶解度 : 100 mg/mL (192.45 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9245 mL 9.6226 mL 19.2452 mL
5 mM 0.3849 mL 1.9245 mL 3.8490 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9245 mL 9.6226 mL 19.2452 mL 48.1130 mL
5 mM 0.3849 mL 1.9245 mL 3.8490 mL 9.6226 mL
10 mM 0.1925 mL 0.9623 mL 1.9245 mL 4.8113 mL
15 mM 0.1283 mL 0.6415 mL 1.2830 mL 3.2075 mL
20 mM 0.0962 mL 0.4811 mL 0.9623 mL 2.4057 mL
25 mM 0.0770 mL 0.3849 mL 0.7698 mL 1.9245 mL
30 mM 0.0642 mL 0.3208 mL 0.6415 mL 1.6038 mL
40 mM 0.0481 mL 0.2406 mL 0.4811 mL 1.2028 mL
50 mM 0.0385 mL 0.1925 mL 0.3849 mL 0.9623 mL
60 mM 0.0321 mL 0.1604 mL 0.3208 mL 0.8019 mL
80 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6014 mL
100 mM 0.0192 mL 0.0962 mL 0.1925 mL 0.4811 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Bomedemstat
目录号:
HY-109169
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