1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. BRD 4354 ditrifluoroacetate

BRD 4354 ditrifluoroacetate 

目录号: HY-112719B 纯度: 98.52%
产品使用指南

BRD 4354 (ditrifluoroacetate) 是 HDAC5HDAC9 抑制剂,其 IC50 值分别为 0.85,1.88 μM。

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BRD 4354 ditrifluoroacetate Chemical Structure

BRD 4354 ditrifluoroacetate Chemical Structure

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥1075 In-stock
5 mg ¥800 In-stock
10 mg ¥1400 In-stock
25 mg ¥2800 In-stock
50 mg ¥4800 In-stock
100 mg ¥8100 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively[1].

IC50 & Target[1]

HDAC5

0.85 μM (IC50)

HDAC9

1.88 μM (IC50)

Molecular Weight

610.93

Formula

C₂₅H₂₅ClF₆N₄O₅

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (204.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6368 mL 8.1842 mL 16.3685 mL
5 mM 0.3274 mL 1.6368 mL 3.2737 mL
10 mM 0.1637 mL 0.8184 mL 1.6368 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References

Purity: 98.52%

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
BRD 4354 ditrifluoroacetate
目录号:
HY-112719B
需求量:

BRD 4354 ditrifluoroacetate

Cat. No.: HY-112719B