2. Epigenetics
  3. Epigenetic Reader Domain
  4. BRD4 Inhibitor-26

BRD4 Inhibitor-26 是一种溴结构域蛋白 4 (BRD4) 抑制剂/一氧化氮供体。BRD4 Inhibitor-26 抑制 BRD4 (BD1) 和 BRD4 (BD2)，IC50 值分别为 0.82 μM 和 1.94 μM。BRD4 Inhibitor-26 可用于卵巢癌的研究。

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BRD4 Inhibitor-26 Chemical Structure

BRD4 Inhibitor-26 Chemical Structure

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BRD4 Inhibitor-26 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 Inhibitor-26 is a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator. BRD4 Inhibitor-26 inhibits BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. BRD4 Inhibitor-26 can be used for the research of ovarian cancer[1].

IC50 & Target

IC50: 0.82 μM (BRD4 (BD1)); 1.94 μM (BRD4 (BD2)); 1.38-8.47 μM (OC cells)[1].
Kd: 0.419 μM (BRD4 (BD1)); 0.686 μM (BRD4 (BD2))[1]
体外研究
(In Vitro)

BRD4 Inhibitor-26 (Compound 11a) 对BRD4 (BD1) 和 BRD4 (BD2) 具有抑制活性，IC50 值分别为 0.82 μM 和 1.94 μM[1]。
BRD4 Inhibitor-26 对 BRD4 (BD1) 和 BRD4 (BD2) 具有抑制活性，Kd 值分别为 0.419 μM 和 0.686 μM[1]。
BRD4 Inhibitor-26 对 OC 细胞具有抑制活性，IC50 值范围为 1.38-8.47 μM[1]。
BRD4 Inhibitor-26 (0, 1.0 和 2.0 μM; 24 h) 显著降低 BRD4 和 c-Myc 的表达，并诱导细胞凋亡和自噬细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-26 相关抗体:

Apoptosis Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 0, 1.0 and 2.0 μM
Incubation Time: 24 h
Result: Increased the percentages of total apoptotic cells and showed dose-dependent in early apoptotic cells.

Western Blot Analysis[1]

Cell Line: SKOV-3 cells
Concentration: 0, 1.0 and 2.0 μM
Incubation Time: 24 h
Result: Up-regulated the classical apoptosis-related proteins Cytochrome c, down-regulated the anti-apoptosis protein Bcl-2 and Cleaved-caspase 3 and also up-regulated the autophagy-related proteins LC3II/I, p62/SQSTM1 and Beclin1.

Immunofluorescence[1]

Cell Line: SKOV-3 cells
Concentration: 2.0 μM
Incubation Time: 24 h
Result: [1]
体内研究
(In Vivo)

BRD4 Inhibitor-26 (腹腔注射; 30 mg/kg) 在体内具有抗肿瘤活性并诱导细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c nude mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal administration
Result: Suppressed the ovarian cancer cells proliferation via BRD4 inhibition and activated apoptosis.
分子量

573.62

Formula

C29H27N5O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 Inhibitor-26 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-26Epigenetic Reader Domainbromodomain protein 4 (BRD4)nitric oxide-donatorovarian cancerInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-152209
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