2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-17

BTK-IN-17 (compound 36R) 是一种选择性且具有 BTK 抑制剂，IC50 值为 13.7 nM。BTK-IN-17 降低 p-BTKY223 和 p-PLCγ2Y1217 的表达。BTK-IN-17 具有抗炎作用。

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BTK-IN-17 Chemical Structure

BTK-IN-17 Chemical Structure

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BTK-IN-17 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTK-IN-17 (compound 36R) is a selective and orally activeBTK inhibitor with an IC50 value of 13.7 nM. BTK-IN-17 decreases the expression of p-BTKY223 and p-PLCγ2Y1217. BTK-IN-17 shows anti-inflammatory effects[1].

IC50 & Target

IC50: 13.7 nM (BTK)[1]
体外研究
(In Vitro)

BTK-IN-17 (compound 36R) shows hERG channel inhibition with an IC50 value of 8.6 µM[1].
BTK-IN-17 (0-10000 nM) decreases the expression of p-BTKY223 and p-PLCγ2Y1217 in Ramos cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-17 相关抗体:

Western Blot Analysis[1]

Cell Line: Ramos cells
Concentration: 0-10000 nM
Incubation Time:
Result: Inhibited phosphorylation of downstream BTK (p-BTKY223) and phosphorylation of PLCγ2 (p-PLCγ2Y1217).
体内研究
(In Vivo)

BTK-IN-17 (1 mg/kg i.v.; 10 mg/kg p.o.) 显示口服给药后一小时血浆浓度迅速达到 125 nM，BTK 占有率达到 79%，BTK 占有率在 24 小时后保持约 62% 在大鼠中[1].
BTK-IN-17 (10, 30, 50 mg/kg; p.o.; once daily for 10 days) 在大鼠中显示出良好的抗炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

465.51

Formula

C26H23N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTK-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-17BtkBruton tyrosine kinaseanti-inflammatoryhERG channelRamos cellsorally activep-BTKY223p-PLCγ2Y1217Inhibitorinhibitorinhibit

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产品名称：
BTK-IN-17
目录号：
HY-151920
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