Cefpiramide  (Synonyms: SM-1652 free acid; Wy-44635 free acid)

Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase^[1][2].

Cefpiramide (0-2048 µg/mL; 16-18 hours) shows good activity to against most non-fermentative Gram-negative bacilli and Enterococci (32 µg/mL with 97% inhibition)^[1].
Cefpiramide (0-2048 µg/mL; 16-18 hours) exhibits high effective to against Pseudomonas aeruginosa with MIC_[50] and MIC_[90] values of 4 µg/mL and 16 µg/mL separately^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cefpiramide (25 mg/kg; i.v.; once) shows anti-Streptococcus pneumoniae activity in experimental pneumococcal meningitis^[2].
Cefpiramide (25 mg/kg; i.v.; once) reduces bacteria in CSF more than 10^[4] CFU/ml^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

612.64

C₂₅H₂₄N₈O₇S₂

70797-11-4

头孢匹胺游离酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Barry AL, et al. Cefpiramide: comparative in-vitro activity and beta-lactamase stability. J Antimicrob Chemother. 1985 Sep;16(3):315-25.  [Content Brief]

  [2]. Sato K, et al. Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis. Antimicrob Agents Chemother. 1984 Oct;26(4):578-9.  [Content Brief]