Cinnamtannin A2  (Synonyms: 肉桂鞣质A2)

Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect^[1][2].

Cinnamtannin A2 (0.125-2.0 μg/mL) inhibits LDL oxidation induced by copper ions or MeO-AMVN^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamtannin A2 (10 mg/kg; i.p. for 30 days) ameliorates the level of KIM1 and NAGL in 5/6 nephractomized rats by regulating Nrf2- Keap1 pathway^[2].
Cinnamtannin A2 (10 μg/kg; p.o.) increases the secretion of insulin and glucagon-like peptide-1 (GLP-1) in plasma of mice^[1].
Cinnamtannin A2 (10 μg/kg; p.o.) significantly promotes phosphorylation of both IRB and IRS-1 in mice^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1155.02

C₆₀H₅₀O₂₄

86631-38-1

肉桂鞣质A2

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yamashita Y, et, al. Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice. Biosci Biotechnol Biochem. 2013;77(4):888-91.  [Content Brief]

  [2]. Li N, et, al. Cinnamtannin A2 protects the renal injury by attenuates the altered expression of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) expression in 5/6 nephrectomized rat model. AMB Express. 2020 May 8;10(1):87.  [Content Brief]

  [3]. Osakabe N, et, al. Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro. Exp Biol Med (Maywood). 2002 Jan;227(1):51-6.  [Content Brief]