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  2. Biochemical Assay Reagents Apoptosis
  3. Clodronate liposomes

Clodronate liposomes  (Synonyms: 氯膦酸盐脂质体)

目录号: HY-172202
COA 产品使用指南 技术支持

Clodronate liposomes 是一种由磷脂体包裹的氯膦酸盐的混合物,是一种巨噬细胞清除剂。Clodronate liposomes 在体内会被巨噬细胞吞噬,在巨噬细胞内的溶酶体磷酸酶的作用下,溶解在脂质体内的氯膦酸盐会被逐步释放出来并在细胞内积累,当达到一定浓度时,巨噬细胞将会受到不可逆损伤,诱发细胞凋亡 (apoptosis)。

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Clodronate liposomes

Clodronate liposomes Chemical Structure

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规格 价格 是否有货 数量
5 mL ¥8800
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50 mL   询价  

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Other Forms of Clodronate liposomes:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clodronate liposomes, a mixture of Clodronate encapsulated by phospholipids, is a macrophage scavenger. Clodronate liposomes is engulfed by macrophages in the body. Under the action of lysosomal phosphatases in macrophages, Clodronate dissolved in liposomes will be gradually released and accumulated in cells. When a certain concentration is reached, macrophages will be irreversibly damaged and apoptosis will be induced[1].

体内研究
(In Vivo)

不同组织巨噬细胞清除的方法 (仅供参考,可根据具体实验优化)

清除 脾脏红髓区和 Kupffer 巨噬细胞:
单次给药:200 μL/小鼠 (静脉注射或腹腔注射)。
长期给药:第一次给药剂量150 μL/小鼠,之后每隔三天给药100 μL/小鼠。

清除 肺泡巨噬细胞
静脉注射 (150-200 μL) 联合气管或鼻内 (50 μL) 给药获得最佳效果。

清除脑部小胶质细胞
脑室脑脊液注射,小鼠 (10 μL),大鼠 (50 μL)。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

性状

液体

颜色

Milky white to off-white

中文名称

氯膦酸盐脂质体

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at 4°C, do not freeze

纯度 & 产品资料

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Clodronate liposomes
目录号:
HY-172202
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