2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. CM03

CM03 是一种有效的 DNA G 四联体 (G4s) 结合分子。CM03 可以稳定 G4s，下调更多含 G4 的基因，并增加由于 DNA 和染色质结构扭转应变导致的双链断裂事件 (DSBs) 的发生率。CM03 对胰腺癌细胞具有选择性作用。

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CM03 Chemical Structure

CM03 Chemical Structure

CAS No. : 2101208-44-8

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规格 价格 是否有货 数量
1 mg ￥1363
In-stock
5 mg ￥3000
In-stock
10 mg ￥4800
In-stock
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Customer Review

CM03 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CM03 is a potent DNA G-quadruplexes (G4s) ligand. CM03 can stabilise G4s, downregulating more G4-containing genes as well as increasing incidence of double-strand break events (DSBs) due to torsional strain on DNA and chromatin structure. CM03 has selective potency for pancreatic cancer cells[1][2].

IC50 & Target

DNA synthesis[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
24 nM
Compound: CM03
Growth inhibition of human A549 cells after 96 hrs by SRB assay
Growth inhibition of human A549 cells after 96 hrs by SRB assay
[PMID: 29356532]
BXPC-3 GI50
15.5 nM
Compound: CM03
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human BxPC3 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
BXPC-3 IC50
19 nM
Compound: CM03
Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
Growth inhibition of human BxPC3 cells after 96 hrs by SRB assay
[PMID: 29356532]
CAPAN-1 IC50
16 nM
Compound: CM03
Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
Growth inhibition of human Capan1 cells after 96 hrs by SRB assay
[PMID: 29356532]
CAPAN-1 GI50
26.5 nM
Compound: CM03
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human Capan1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
MCF7 IC50
159 nM
Compound: CM03
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
Growth inhibition of human MCF7 cells after 96 hrs by SRB assay
[PMID: 29356532]
MIA PaCa-2 GI50
400 nM
Compound: CM03
Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human MIAPaCa2 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 29356532]
MIA PaCa-2 IC50
7 nM
Compound: CM03
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay
[PMID: 29356532]
MIA PaCa-2 GI50
9 nM
Compound: CM03
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
PANC-1 GI50
15.6 nM
Compound: CM03
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
Antiproliferative activity against human PANC1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 32832034]
PANC-1 IC50
18 nM
Compound: CM03
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
Growth inhibition of human PANC1 cells after 96 hrs by SRB assay
[PMID: 29356532]
PANC-1 GI50
400 nM
Compound: CM03
Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
Growth inhibition of human PANC1 cells after 24 hrs by CellTiter-Glo luminescent cell viability assay
[PMID: 29356532]
WI-38 IC50
1190 nM
Compound: CM03
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
Growth inhibition of human WI38 cells after 96 hrs by SRB assay
[PMID: 29356532]
体外研究
(In Vitro)

CM03 (0.4 μM; 24 or 48 h) increases the level of γ-H2AX protein when in combination with SAHA (HY-10221) in MIA PaCa-2 and PANC-1[1].
CM03 (0-100 nM; 96 h) exhibits highly anti-proliferative activity against pancreatic cancer cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CM03 相关抗体:

Western Blot Analysis[1]

Cell Line: MIA PaCa-2 and PANC-1
Concentration: 0.4 μM
Incubation Time: 24 h for MIA PaCa-2, 48 h for PANC-1
Result: Significantly increased the level of γ-H2AX protein when in combination with SAHA (HY-10221) (1 μM).

Cell Proliferation Assay[2]

Cell Line: MIA PaCa-2, PANC-1, Capan-1 and BxPC-3
Concentration: 0-100 nM
Incubation Time: 96 h
Result: Exhibited highly anti-proliferative activity against pancreatic cancer cell lines with GI50s of 9.0 nM, 15.6 nM, 26.5 nM and 15.5 nM in MIA PaCa-2, PANC-1, Capan-1 and BxPC-3, respectively.
分子量

632.75

Formula

C34H44N6O6
CAS 号
性状

固体

颜色

Brown to dark brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 2 mg/mL (3.16 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5804 mL 7.9020 mL 15.8040 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.73%

COA (287 KB) HNMR (295 KB) LCMS (93 KB)

产品使用指南 (1538 KB)
参考文献

CM03 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5804 mL 7.9020 mL 15.8040 mL 39.5101 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CM032101208-44-8CM 03CM-03DNA/RNA SynthesisDSBsDNAchromatinpancreatic cancerInhibitorinhibitorinhibit

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