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  3. Cobalt protoporphyrin IX

Cobalt protoporphyrin IX  (Synonyms: Co-PPIX)

目录号: HY-134608
产品使用指南

Cobalt protoporphyrin IX (Co-PPIX) 是一种有效的特异性血红素加氧酶-1 (HO-1) 诱导剂。Cobalt protoporphyrin IX 对甲型流感病毒 (IAV) 具有广谱抗病毒活性。

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Cobalt protoporphyrin IX Chemical Structure

Cobalt protoporphyrin IX Chemical Structure

CAS No. : 14325-03-2

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Cobalt protoporphyrin IX (Co-PPIX) is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV)[1].

体外研究
(In Vitro)

Cobalt protoporphyrin IX (2 μM; 0-24 h) 在 MDCK 细胞和 RAW264.7 细胞中以时间依赖的方式增加 HO-1 细胞内蛋白水平[1]
Cobalt protoporphyrin IX 对 Empty Cell A/FortMonmouth /1/1947、A/TianjinJinnan /15/2009、A/Wuhan /359/1995、A/FujianTongan /196/2009 和 BY/FujianXinluo /54/2006 流感病毒的 IC50分别为 0.40 ± 0.16、0.42 ± 0.15、0.46 ± 0.19、0.34 ± 0.05 和 0.64 ± 0.30 μM[1]
Cobalt protoporphyrin IX (0.25-2 μM; 18 or 24 h) 通过增强 IFN 反应抑制 IAV 复制,抗 IAV 活性不依赖于 HO-1 的催化功能[1]
Cobalt protoporphyrin IX (2 μM; 0-6 h) 诱导 HO-1 抗 IAV 活性可能依赖于 IRF3 磷酸化和易位,以增强抗病毒 IFN 应答[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDCK cells and RAW264.7 cells
Concentration: 2 μM
Incubation Time: 0, 3, 6, 12 and 24 h
Result: Significantly increased the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells.

Real Time qPCR[1]

Cell Line: RAW264.7 cells were infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
Concentration: 0.25, 0.5, 1 and 2 μM
Incubation Time: 18 h
Result: Enhanced mRNA expressions of IFN-α/β, as well as protein expressions of some ISGs, such as IFN-inducible transmembrane protein 3 (IFITM3), double-stranded RNA-dependent protein kinase (PKR) and 2′-5′-oligoadenylate synthetase 1 (OAS1), in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells or RAW264.7 cells infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI)
Concentration: 2 μM
Incubation Time: 0, 2, 4 and 6 h
Result: Increased protein levels of IRF3 and p-IRF3. Promoted the cytoplasmic protein levels of IRF3 and p-IRF3 in RAW264.7 cells following the enhancement of HO-1 protein expression after 6 h. Induced nuclear IRF3 and nuclear p-IRF3 accumulation within 6 h of treatment.
分子量

619.58

Formula

C34H32CoN4O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Cobalt protoporphyrin IX
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