Croscarmellose sodium 

Croscarmellose sodium is a commonly used pharmaceutical additive approved by the US Food and Drug Administration (FDA). Croscarmellose sodium is used as excipients, such as the suspending agent, binder, glidant, antiadherent, and disintegrants^[1][2].

Croscarmellose sodium 是一种常用的药用辅料。药用辅料是指在制药过程中使用的除药物成分以外的非活性化学物质，能够改善药物制剂的稳定性、溶解性和可加工性。药用辅料还会影响合并用药的吸收、分布、代谢和消除 (ADME) 过程^[2]。
Croscarmellose sodium 可促进难溶性化合物在水中溶解，在注射剂中作为助悬剂。Croscarmellose sodium 作为片剂的润滑剂，可提高药物的流动性。Croscarmellose sodium 作为抗粘剂，可防止药物颗粒粘附在模具上。Croscarmellose sodium 作为崩解剂，可快速吸收水分并膨胀，使药物在胃肠道中快速崩解，从而加速药物的释放和吸收。Croscarmellose sodium 还可作为食品工业中的添加剂，用于增稠或稳定^[1][3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Croscarmellose sodium 几乎不经胃肠道吸收。在某些情况下，例如肠道通透性增加（例如，由于炎症性肠病或肠道感染引起），Croscarmellose sodium 可能会被部分吸收，从而引发过敏反应，如瘙痒、皮疹、呼吸困难^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

74811-65-7

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Mumoli N, et al. Allergic reaction to Croscarmellose sodium used as excipient of a generic drug. QJM. 2011 Aug;104(8):709-10.  [Content Brief]

  [2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  [Content Brief]

  [3]. Gordon MS, et al., Effect of the mode of croscarmellose sodium incorporation on tablet dissolution and friability. J Pharm Sci. 1990 Jan;79(1):43-7.  [Content Brief]