2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. CS-003 Free base

CS-003 Free base (CS-003) 是一种三速激肽受体拮抗剂，对人神经激肽 (Neurokinin) NK1，NK2 和 NK3 受体具有高亲和力，Ki 值分别为 2.3 nM，0.54 nM 和 0.74 nM。 CS-003 Free base 可用于与神经激肽有关的呼吸系统疾病的研究。

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CS-003 Free base Chemical Structure

CS-003 Free base Chemical Structure

CAS No. : 191672-52-3

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CS-003 Free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CS-003 Free base (CS-003), a triple tachykinin receptor antagonist, shows high affinities for human (Neurokinin) NK1, NK2 and NK3 receptors with Ki values of 2.3 nM, 0.54 nM and 0.74 nM, respectively. CS-003 Free base (CS-003) has therapeutic efficacy on respiratory diseases associated with neurokinins.

IC50 & Target

NK1

2.3 nM (Ki)

NK2

0.54 nM (Ki)

NK3

0.74 nM (Ki)

体外研究
(In Vitro)

CS-003 (0.01-10 μM; 24 hours) inhibits NK1, NK2 or NK3 induced inositol phosphate formation in a concentration-dependent manner with pA2 values of 8.7, 9.4 and 9.5 μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CS-003 Free base 相关抗体:
体内研究
(In Vivo)

CS-003 (intravenous injection; 0.01-3.0 mg/kg; 5 min before neurokinin A/B/C injection) inhibits substance P-induced tracheal vascular hyperpermeability, neurokinin A- and neurokinin B-induced bronchoconstriction with ID50 values of 0.13, 0.040 and 0.063 mg/kg, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

673.65

Formula

C34H38Cl2N2O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CS-003 Free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CS-003191672-52-3CS003CS 003Neurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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CS-003 Free base
目录号：
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