2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. CV-6209

CV-6209 是一种有效的血小板激活因子 (PAF) 拮抗剂。CV-6209 抑制 PAF 诱导的兔和人血小板聚集，IC50 值分别为 75 nM 和 170 nM。CV-6209 可以抑制 PAF 引起的大鼠低血压。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CV-6209 Chemical Structure

CV-6209 Chemical Structure

CAS No. : 100488-87-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥1600
In-stock
5 mg ￥6900
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

CV-6209 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CV-6209 is a potent antagonist of platelet activating factor (PAF). CV-6209 inhibits the PAF-induced aggregation of rabbit and human platelets, with IC50s of 75 nM and 170 nM, respectively. CV-6209 can inhibit PAF-induced hypotension in rats[1].

IC50 & Target

platelet activating factor (PAF)[1]
体外研究
(In Vitro)

CV-6209 inhibits [3H]serotonin release from rabbit platelets stimulated with PAF (30 nM)[1].
CV-6209 has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen[1].
CV-6209 (0.2-2 μM; pretreated for 30 min) inhibits PAF-induced MC degranulation in both LAD2 and hLMCs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CV-6209 相关抗体:
体内研究
(In Vivo)

CV-6209 (i.v.) inhibits PAF (0.3 μg/kg; i.v.)-induced hypotension in rats (ED50=0.009 mg/kg) with no effect on the hypotension induced by arachidonic acid, histamine, bradykinin and isoproterenol[1].
CV-6209 (66 μg; i.v.) reduces asparaginase-induced hypersensitivity compared with nonpretreated, sensitized mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

642.31

Formula

C34H60ClN3O6
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (155.69 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5569 mL 7.7844 mL 15.5688 mL
5 mM 0.3114 mL 1.5569 mL 3.1138 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (185 KB) HNMR (132 KB)

产品使用指南 (1538 KB)
参考文献

CV-6209 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5569 mL 7.7844 mL 15.5688 mL 38.9220 mL
5 mM 0.3114 mL 1.5569 mL 3.1138 mL 7.7844 mL
10 mM 0.1557 mL 0.7784 mL 1.5569 mL 3.8922 mL
15 mM 0.1038 mL 0.5190 mL 1.0379 mL 2.5948 mL
20 mM 0.0778 mL 0.3892 mL 0.7784 mL 1.9461 mL
25 mM 0.0623 mL 0.3114 mL 0.6228 mL 1.5569 mL
30 mM 0.0519 mL 0.2595 mL 0.5190 mL 1.2974 mL
40 mM 0.0389 mL 0.1946 mL 0.3892 mL 0.9731 mL
50 mM 0.0311 mL 0.1557 mL 0.3114 mL 0.7784 mL
60 mM 0.0259 mL 0.1297 mL 0.2595 mL 0.6487 mL
80 mM 0.0195 mL 0.0973 mL 0.1946 mL 0.4865 mL
100 mM 0.0156 mL 0.0778 mL 0.1557 mL 0.3892 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CV-6209100488-87-7CV6209CV 6209Platelet-activating Factor Receptor (PAFR)plateletactivatingfactorPAFaggregationplateletshypotensionInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CV-6209
目录号：
HY-109897
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z