Dapsone-d₈  (Synonyms: 4,4′-Diaminodiphenyl sulfone-d₈; DDS-d₈)

Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

氨苯砜 (0.06 mM; 30 min) 抑制 N-Formyl-Met-Leu-Phe (HY-P0224) (1 μM) 和生理激动剂 C5a (100 nM) 触发的细胞内外超氧化物 (O₂^-) 和胰蛋白酶 E 的释放，而不是对 Phorbol 12-myristate 13-acetate (HY-18739) (100 nM) 没有作用^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

氨苯砜 (5 mg/kg; i.p.; 单次给药) 具有神经保护作用，显著改进了 Scopolamine (HY-N0296) 诱导记忆损伤小鼠的记忆获取能力^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

256.35

C₁₂H₄D₈N₂O₂S

557794-38-4

固体

White to off-white

氨苯砜 d₈

Room temperature in continental US; may vary elsewhere.

• [1]. Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol  [Content Brief]

  [2]. Dapsone. Drug.com

  [3]. D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.  [Content Brief]

  [4]. Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.  [Content Brief]

  [5]. Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306(2):103-24.  [Content Brief]

  [6]. Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12(1):43-50.  [Content Brief]