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  6. Delphinidin-3-sambubioside chloride

Delphinidin-3-sambubioside chloride  (Synonyms: Dp3‐Sam chloride)

目录号: HY-129143
产品使用指南

摩尔计算器

Delphinidin-3-sambubioside (Dp3-Sam) chloride 一种具有口服活性的花青素，具有抗炎活性。Delphinidin-3-sambubioside chloride 抑制 LPS 诱导的炎症因子释放。Delphinidin-3-sambubioside chloride 还可以减轻 HFD 大鼠的肝脏脂质积累。Delphinidin-3-sambubioside chloride 可以从 Hibiscus sabdariffa L. 中分离出来。

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Delphinidin-3-sambubioside chloride Chemical Structure

Delphinidin-3-sambubioside chloride Chemical Structure

CAS No. : 53158-73-9

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Delphinidin-3-sambubioside chloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated from Hibiscus sabdariffa L.[1][3].

体外研究
(In Vitro)

Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50 of 75 μM[2].
Delphinidin-3-sambubioside chloride (100-200 µg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Delphinidin-3-sambubioside chloride 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 50, 100, 200 μM
Incubation Time: 30 min
Result: Suppressed the degradation of IκB, and the phosphorylation of p65.
体内研究
(In Vivo)

Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累[3]。
Dosage: 15 μmol/kg
Administration: Intraperitoneal injection (i.p.), for 4 days.
Result: Reduced the LPS-induced paw thickness.
Decreased the edema by 89.3%.
Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α.
Animal Model: HFD-fed rats[3]
Dosage: 30 mg/kg
Administration: Oral gavage, daily for eight weeks.
Result: Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits.
分子量

632.95

Formula

C26H29ClO16
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Delphinidin-3-sambubioside53158-73-9Dp3‐SamOthersAnthocyaninRAW264.7paw edemaLPSHepG2HFD ratlipid accumulationInhibitorinhibitorinhibit

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