2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Delta3,5-cholestadien-7-one

Delta3,5-cholestadien-7-one 是一种羟甾醇，是 GABAA receptors 的负变构调节剂。Delta3,5-cholestadien-7-one 在表达含有 α1β1γ2 或 α4β3γ2 亚基的 GABAA 受体的 HEK 细胞中降低 GABA 诱导的电流，IC50 值分别为 1.5 和 1 µM。在离体小鼠背根神经节 (DRG) 神经元中，Delta3,5-cholestadien-7-one 减少 GABA 诱导的肽能和非肽能伤害感受器、C-LTMRs 和冷热感受器的去极化。

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Delta3,5-cholestadien-7-one

Delta3,5-cholestadien-7-one Chemical Structure

CAS No. : 567-72-6

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Delta3,5-cholestadien-7-one 相关抗体

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生物活性

Delta3,5-cholestadien-7-one is an oxysterol and a negative allosteric modulator of GABAA receptors. Delta3,5-cholestadien-7-one reduces GABA-induced currents in HEK cells expressing α1β1γ2 or α4β3γ2 subunit-containing GABAA receptors with IC50 values of 1.5 and 1 µM, respectively. Delta3,5-cholestadien-7-one reduces GABA-induced depolarization of peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion (DRG) neurons[1][2].

分子量

382.62

Formula

C27H42O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Delta3,5-cholestadien-7-one 相关分类

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Keywords:

Delta3,5-cholestadien-7-one567-72-6GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorOxysterolGABAAHEK cellsC-LTMRsInhibitorinhibitorinhibit

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