2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Autophagy
  3. Herbicide Reactive Oxygen Species (ROS) Mitochondrial Metabolism Autophagy
  4. Diquat dibromide

Diquat dibromide  (Synonyms: 敌草快二溴盐)

目录号: HY-122984 纯度: 99.86%
COA 产品使用指南 技术支持

Diquat dibromide 是一种综合性除草剂 (herbicide)。Diquat dibromide 增加 ROS 的产生、触发线粒体自噬 (mitochondrial Autophagy)。Diquat dibromide 通过氧化还原循环产生超氧阴离子等自由基，引发氧化应激反应。Diquat dibromide 具有细胞、生殖和神经毒性。Diquat dibromide 用于棉花、大豆和其他作物的种植，以对抗有害杂草。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Diquat dibromide Chemical Structure

Diquat dibromide Chemical Structure

CAS No. : 85-00-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
25 mg ￥690
In-stock
50 mg ￥1100
In-stock
100 mg ￥1750
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Diquat dibromide:

Diquat dibromide 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds[1][2][3][4][5][6][7][8].

体外研究
(In Vitro)

Diquat (10-20 μM；20 h) dibromide 会导致 SH-SY5Y 细胞死亡[3]。
Diquat (50 μM) dibromide 会诱导培养的背根神经节 (DRG) 神经元的轴突变性[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diquat dibromide 相关抗体:
体内研究
(In Vivo)

Diquat (10 mg/kg体重；腹腔注射) dibromide 可诱导仔猪氧化应激，增加肠道通透性，损害线粒体功能，并触发线粒体自噬[2]。
Diquat dibromide (25 mg/L饮用水；10 周) 可降低成年雄性斑胸草雀喙红色素和血浆总类胡萝卜素含量，并提高其亲脂性抗氧化能力[4]。
Diquat (8-12 mg/kg；腹腔注射；每周两次；4 周) dibromide 可导致雌性小鼠生殖毒性[6]。
Diquat (10 mg/kg；腹腔注射；每周两次；6 周) 对雄性 C57/BL-6 小鼠表现出神经毒性，诱发运动功能障碍 (如运动迟缓、步态异常、游泳能力下降等)[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twelve male Duroc × Landrace × Yorkshire 35-d-old pigs (weaned at 21 d of age), with an average body weight of 9.6 kg, used as a model for studying the effect of Diquat-induced oxidative stress on intestinal barrier, mitochondrial function, and mitophagy[2].
Dosage: 10 mg/kg BW (dissolved in 0.9% NaCl solution)
Administration: Intraperitoneal injection
Result: Significantly decreased ADFI and ADG.
Impaired the intestinal barrier function, as indicated by a decrease in TER, an increase in FD4 flux, and a reduction in the protein abundance of claudin-1, occludin, and zonula occludens-1.
Caused mitochondrial dysfunction, with increased ROS production, decreased membrane potential in intestinal mitochondria, and a decrease in the mRNA abundance of genes related to mitochondrial biogenesis and function.
Triggered mitophagy, as shown by the increased expression of mitophagy-related proteins and the increased ratio of LC3-II to LC3-I.
Animal Model: Female ICR mice[6]
Dosage: 8 mg/kg or 12 mg/kg (dissolved in normal saline)
Administration: Intraperitoneal injection, twice a week, for 4 weeks
Result: Significantly reduced ovary weights compared with control mice.
Decreased the percentage of normal GV oocytes and polar body extrusion.
Significantly increased ROS production in follicular granulosa cells and oocytes.
Decreased the activities of antioxidant enzymes (T-SOD, GPx and CAT) in the serum, and increased the MDA content.
Reduced the average numbers of fetus and litter size on GD 7.5 d.
分子量

344.05

Formula

C12H12Br2N2
CAS 号
性状

固体

颜色

Light yellow to yellow

中文名称

敌草快二溴盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.86%

COA (292 KB) HNMR (249 KB) LCMS (92 KB)

产品使用指南 (1538 KB)
参考文献

Diquat dibromide 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diquat dibromide85-00-7敌草快二溴盐HerbicideReactive Oxygen Species (ROS)Mitochondrial MetabolismAutophagyherbicidecottonsoybeanscropsweedsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Diquat dibromide
目录号：
HY-122984
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z