2. GPCR/G Protein
  3. CRFR
  4. E-2508 free base

E-2508 free base 是一种口服活性且高度选择性的促肾上腺皮质激素释放因子 1 型受体 (CRF1) 拮抗剂，具有抗焦虑作用 (IC50=11 nM)。E-2508 free base 通过抑制 CRF1 受体来阻断 CRF 引起的 cAMP 积累。E-2508 free base 有望用于与压力相关的精神疾病 (如焦虑症和抑郁症) 的研究。

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E-2508 free base

E-2508 free base Chemical Structure

CAS No. : 685885-75-0

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E-2508 free base 相关抗体

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CRFR1 CRFR2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (IC50=11 nM). E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression[1].

分子量

493.64

Formula

C29H39N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E-2508 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E-2508685885-75-0E2508E 2508CRFRCorticotropin-releasing Factor ReceptorCRHRorally activeCRF1stress-related psychiatric disordersInhibitorinhibitorinhibit

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产品名称：
E-2508 free base
目录号：
HY-119114
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