2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. E-4031 free base

E-4031 free base 是一种选择性 hERG 钾通道阻断剂，可用于 III 类抗心律失常研究。

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E-4031 free base

E-4031 free base Chemical Structure

CAS No. : 113558-89-7

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E-4031 free base 的其他形式现货产品:

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E-4031 free base 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

E-4031 free base is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
0.024 μM
Compound: E-4031
Inhibition of human ERG expressed in CHOK1 cells assessed as inhibition of tail current after 5 mins by automated whole-cell patch clamp assay
Inhibition of human ERG expressed in CHOK1 cells assessed as inhibition of tail current after 5 mins by automated whole-cell patch clamp assay
[PMID: 27105029]
COS-7 IC50
10.2 nM
Compound: E-4031
Inhibition of hERG Voltage-gated potassium channel subunit Kv11.1 expressed in COS7 cells by electrophysiological whole cell assay
Inhibition of hERG Voltage-gated potassium channel subunit Kv11.1 expressed in COS7 cells by electrophysiological whole cell assay
[PMID: 15084130]
HEK293 IC50
0.027 μM
Compound: E-4031
Inhibition of human ERG expressed in HEK293 cells by patch clamp assay
Inhibition of human ERG expressed in HEK293 cells by patch clamp assay
[PMID: 32298114]
Ventricular myocyte IC50
441 μM
Compound: E-4031
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes
[PMID: 22761000]
分子量

401.52

Formula

C21H27N3O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

E-4031 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E-4031113558-89-7E4031E 4031Potassium ChannelKcsAhERGpotassium channelanti-arrhythmicInhibitorinhibitorinhibit

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E-4031 free base
目录号：
HY-15551A
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