2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Endothall

Endothall  (Synonyms: 草藻灭; Endothal)

目录号: HY-113976A 纯度: ≥95.0%
COA 产品使用指南

摩尔计算器

Endothall (Endothal) 是一种蛋白磷酸酶 2A (PP2A) 抑制剂，对 PP2A 和 PP1 的 IC50 分别为 90 nM 和 5 µM。Endothall 可用作除草剂。Endothall 在癌症化疗中也很有用。

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Endothall Chemical Structure

Endothall Chemical Structure

CAS No. : 145-73-3

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规格 价格 是否有货 数量
5 mg ￥2500
In-stock
10 mg ￥3875
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Endothall 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Endothall (Endothal) is a protein phosphatase 2A (PP2A) inhibitor with IC50s of 90 nM and 5 µM for PP2A and PP1, respectively. Endothall can be used as an herbicide. Endothall also is useful in cancer chemotherapy[1].

体外研究
(In Vitro)

Endothall, an organic acid, is the least toxic structural analogue of Cantharidin that still inhibits PP2A[2].
Endothall inhibits preferentially hepatocellular carcinoma (HCC) growth and these new rat hepatocellular carcinoma lines may be useful for further biochemical and pharmacological studies on PP2A inhibitors, and for testing new forms of treatment of hepatic cell carcinomas. The HR-2, HR-3, HR-4, and Zajdela hepatocellular carcinomas are most sensitive to Endothall (IC50 of 1.7, 1.2, 0.9, and 1.7 µg/mL), whereas newborn rat hepatocytes growing exponentially in primary culture (IC50=6.2 µg/mL), rat DHD/K12 colon carcinoma cells (IC50=3.6 µg/mL), or human HT-29 colon carcinoma cells (IC50=4.9 µg/mL) were less sensitive[2].
Endothall inhibits the growth of HCC lines in culture more than that of normal hepatocytes or colon carcinomas, inducing mitotic arrest, followed by cell death. Endothall causes dose- and time-dependent cytostasis specifically in G2/M[2].
Endothall (3 µg/mL) inhibits the cell cycle at G2/M and subsequent apoptotic cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Endothall 相关抗体:
体内研究
(In Vivo)

Endothall exhibits acute LD50 of 14 mg/kg in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

186.16

Formula

C8H10O5
CAS 号
性状

固体

颜色

White to off-white

中文名称

茵多杀；草藻灭；草多索；藻草灭
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (537.17 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.3717 mL 26.8586 mL 53.7172 mL
5 mM 1.0743 mL 5.3717 mL 10.7434 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥95.0%

COA (200 KB)

产品使用指南 (1538 KB)
参考文献

Endothall 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3717 mL 26.8586 mL 53.7172 mL 134.2931 mL
5 mM 1.0743 mL 5.3717 mL 10.7434 mL 26.8586 mL
10 mM 0.5372 mL 2.6859 mL 5.3717 mL 13.4293 mL
15 mM 0.3581 mL 1.7906 mL 3.5811 mL 8.9529 mL
20 mM 0.2686 mL 1.3429 mL 2.6859 mL 6.7147 mL
25 mM 0.2149 mL 1.0743 mL 2.1487 mL 5.3717 mL
30 mM 0.1791 mL 0.8953 mL 1.7906 mL 4.4764 mL
40 mM 0.1343 mL 0.6715 mL 1.3429 mL 3.3573 mL
50 mM 0.1074 mL 0.5372 mL 1.0743 mL 2.6859 mL
60 mM 0.0895 mL 0.4476 mL 0.8953 mL 2.2382 mL
80 mM 0.0671 mL 0.3357 mL 0.6715 mL 1.6787 mL
100 mM 0.0537 mL 0.2686 mL 0.5372 mL 1.3429 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Endothall145-73-3Endothal茵多杀草藻灭草多索藻草灭PhosphatasePP2A inhibitorPP2Aherbicidecancer chemotherapyInhibitorinhibitorinhibit

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