1. Autophagy
  2. Autophagy
  3. Euxanthone

Euxanthone  (Synonyms: 优咕吨酮)

目录号: HY-N3883
产品使用指南

Euxanthone 是一种氧杂蒽酮衍生物,可通过触发自噬 (autophagy) 来减弱 Aβ1-42 诱导的氧化应激和细胞凋亡。Euxanthone 具有抗肿瘤和神经保护活性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Euxanthone Chemical Structure

Euxanthone Chemical Structure

CAS No. : 529-61-3

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Euxanthone, a xanthone derivative, attenuates Aβ1-42-induced oxidative stress and apoptosis by triggering autophagy. Euxanthone exhibits anti-neoplastic and neuroprotective activities[1][2][3].

体外研究
(In Vitro)

Euxanthone (10-20 μM; 24 h) 损害 OS 细胞以剂量依赖方式迁移的能力,并显着抑制细胞侵袭。Euxanthone 显着降低与纤连蛋白的粘附[1]
Euxanthone (10-20 μM; 24 h) 通过 miR-21/PDCD4/c-jun 信号通路调节 COX-2 的表达。Euxanthone 对 COX-2 的抑制介导了其抗转移活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay [1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Inhibited cell migration at 24 hr.

Western Blot Analysis[1]

Cell Line: Osteosarcoma (OS) cells
Concentration: 10 μM, 20 μM
Incubation Time: 24 h
Result: Repressed both the mRNA and protein level of COX-2 in OS cells in a dose-dependent fashion.
体内研究
(In Vivo)

在肺转移模型中,Euxanthone (40-80 mg/kg) 可显着减少肺组织中转移结节的数量[1]
Euxanthone(30-60 mg/kg;口服;每天一次;持续 7 天)处理使双侧颈总动脉闭塞的小鼠 Bnip3、Beclin1、Pink1、Parkin、p53、Bax、caspase-3 和 LC3 II/I 正常化。Euxanthone 调节由线粒体断裂介导的线粒体应激诱导的线粒体自噬和细胞凋亡[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Forty male ICR mice (20 g) induced cerebral ischemia and reperfusion[2]
Dosage: 30 mg/kg, 60 mg/kg
Administration: p.o.;once a day; for 7 days
Result: Markedly attenuated BCCAO triggered mitochondrial stress and related breakdown.
分子量

228.20

Formula

C13H8O4

CAS 号
中文名称

优咕吨酮

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Euxanthone 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Euxanthone
目录号:
HY-N3883
需求量: