1. Metabolic Enzyme/Protease
    Neuronal Signaling
  2. FAAH
  3. FAAH-IN-6

FAAH-IN-6 

目录号: HY-103461
产品使用指南

FAAH-IN-6 (compound 21d) 是一种有效的、具有口服活性并能穿过血脑屏障的脂肪酸酰胺水解酶 (FAAH) 抑制剂,hFAAH、rFAAH 的 IC50s 分别为 0.72、0.28 nM。FAAH-IN-6 在神经性和炎症性疼痛动物模型中均显示出剂量依赖性镇痛效果。

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FAAH-IN-6 Chemical Structure

FAAH-IN-6 Chemical Structure

CAS No. : 1143578-94-2

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Top Publications Citing Use of Products
  • 生物活性

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  • 参考文献

生物活性

FAAH-IN-6 (compound 21d) is a potent, orally active and cross the blood-brain barrier fatty acid amide hydrolase (FAAH) inhibitor with IC50s of 0.72, 0.28 nM for hFAAH, rFAAH, respectively. FAAH-IN-6 shows dose-dependent analgesic efficacy in animal models of both neuropathic and inflammatory pain[1].

IC50 & Target

IC50: 0.72 nM (hFAAH); 0.28 nM (rFAAH)[1]

体内研究
(In Vivo)

FAAH-IN-6 (compound 21d) (1-10 mg/kg; p.o.) shows significantly ameliorates tactile allodynia in a dose-dependent fashion in SNI-induced neuropathic pain rats model[1].
FAAH-IN-6 (3-10 mg/kg; p.o.) shows significantly ameliorates tactile allodynia of the ipsilateral hind paw in CFA-induced inflammatory pain model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

397.38

Formula

C19H17F2N7O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
FAAH-IN-6
目录号:
HY-103461
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